Bronchiolitis obliterans refers to lung bronchiole injury caused by infection or other reasons, coughing and wheezing that last more than 6 weeks, with or without breathing difficulties, exercise intolerance, which seriously affects physical and mental health and life Quality chronic airflow limitation syndrome.Bronchiolitis obliterans is mainly manifested by coughing and wheezing. Generally, there are 2-4 days of low-grade fever, nasal congestion and runny nose, accompanied by symptoms of lower respiratory tract diseases, including cough, shortness of breath, nasal inflammatory and tri-concave signs. You can hear expiratory wheezing during auscultation. A small number of severely ill children can develop heart failure or respiratory failure, or even life-threatening. Although bronchiolitis has a high cure rate, some children die, and it is closely related to repeated wheezing and the development of asthma in the future, even endangering children health. Bronchiolitis is associated with many risk factors, including premature birth, passive smoking, young age, lack of breastfeeding, malnutrition, chronic lung disease, congenital heart disease, atrioventricular block, male, ethnicity, viral infection , Low weight at admission, multiple pregnancy, mother smoking during pregnancy, allergic dermatitis, neonatal mechanical ventilation, mothers with allergies or asthma during pregnancy, season of birth, low socioeconomic status, Down syndrome, environmental pollution , Living environment height>2500 meters above sea level and cesarean section, etc. In order to study the clinical features and imaging of bronchiolitis obliterans, this article investigates the pathological characteristics of 100 patients from the hospital and conducts a follow-up survey of these 100 patients to understand the prognostic treatment of patients during and after treatment. The study found that the prevalence of bronchiolitis obliterans in infants under 1 year old is about 18-32%, the prevalence of children under 2 years old is 9-17%, and the prevalence of infants under 2 years old is about 1-3%. Children with bronchiolitis require hospitalization. Children with bronchiolitis obliterans are prone to have diarrhea during the course of their illness. In addition, myocardial damage and liver damage may also occur, and a small number of patients have heart failure, respiratory failure, and even endanger the life of the child. This shows that bronchiolitis obliterans is extremely harmful to children and needs to be paid attention to by parents and experts, and be prepared in its early and prognostic treatment.

McMaster Ellen. Clinical Features and Imaging Studies of Bronchiolitis Obliterans. International Journal of Public Health and Preventive Medicine (2021), Vol. 2, Issue 4: 58-70. https://doi.org/10.38007/IJPHPM.2021.020405.

[1] Liang Dongge, Han Zhiying. Clinical analysis of 30 children with bronchiolitis obliterans. Chinese Medicines and Clinics, 2016, 16(03):421-423.

[2] Zhao Zhipeng, Liu Xiuyun. Comparison of clinical features in children with bronchiolitis obliterans in different conditions. Chinese Journal of Practical Pediatrics, 2015, 030(008):605-609.

[3] Xia Liping, Jiang Yi. Research progress of bronchiolitis obliterans in children. Chinese Journal of Applied Clinical Pediatrics, 2015, 001(30):1754-1757.

[4] Han Qing, Shi Yu, Li Hongxia, et al. A case of childhood bronchitis obliterans with bronchiolitis obliterans with organizing pneumonia and literature review. Chinese Journal of Pediatrics, 2016, 54(000):523-526.

[5] Zhang Fudong, Tuan Rongrong, Yang Ruishan, et al. Diagnostic value of multi-slice spiral CT in children with bronchiolitis obliterans. Journal of Practical Medical Techniques, 2016, 23(04):374-375.

[6] Zhuang Juan, Wu Depei, Gu Bin, et al. Clinical analysis of bronchiolitis obliterans syndrome after haplotype hematopoietic stem cell transplantation. Chinese Journal of Hematology, 2019, 040(005):404-410.

[7] Zhao Shunying, Wen Xiaohui. Early recognition and treatment of bronchiolitis obliterans after severe infection. Chinese Pediatric Emergency Medicine, 2017, 24(12):881-882,887.

[8] Dai Ge, Wang Ting, Jiang Wujun, et al. Clinical analysis of 37 cases of bronchiolitis obliterans after adenovirus pneumonia. Chinese Journal of Applied Clinical Pediatrics, 2020, 35(16):1235-1238.

[9] Zheng Yinglian, Mao Guoqi. The relationship between serum antineutrophil cytoplasmic antibodies and diagnosis and treatment of bronchiolitis obliterans in children. Labeled Immunoassays and Clinics, 2020, v.27; No.159(01):75- 78.

[10] Yuan Liyuan. Bronchiolitis obliterans and bronchiolitis tidal breathing lung function and exhaled nitric oxide changes. Jilin University, 2015, 03(16):123-125.

[11] Xi Jicheng, Zhang Zhibiao, Wang Chongjun, et al. Simvastatin combined with cyclosporin A inhibits the occurrence of bronchiolitis obliterans in a heterotopic tracheal transplantation model in mice. Chinese Journal of Organ Transplantation, 2019, 040(009):558- 562.

[12] Liu Ting, Liu Xiaohong, Li Jianqiang. A case of bronchiolitis obliterans with organizing pneumonia. Clinical Medicine Practice, 2017, 004(007):58- 62.

[13] Tang Yan, Liu Cheng, Bi Wanli, et al. Dual-source Flash CT manifestations of bronchiolitis obliterans in children after infection and preliminary study of its relationship with pathology. Journal of Clinical Radiology, 2015, 34(010):1650 -1654.

[14] Huang Wenxian, Wang Yulei, Xu Shoujun, et al. Clinical features and HRCT manifestations of bronchiolitis obliterans in children after infection. Chinese Journal of CT and MRI, 2015, 001(12):7-10.

[15] Chen Fujiang, Wu Tiefeng, Wu Chaoxiong, et al. Clinical analysis of bronchiolitis obliterans after measles pneumonia in children. Chinese General Practice, 2015, 13(010):1645-1647.

[16] Li Sijie. Research progress of bronchiolitis obliterans in children. International Journal of Pediatrics, 2017, 044(005):316-319,323.

[17] Yang Ting, Rao Huaping, Jin Shijie, et al. Clinical observation of terbutaline combined with budesonide nebulized inhalation in the treatment of infantile bronchiolitis obliterans after infection. Journal of Pediatric Pharmacy, 2016, 022(007):19-21.

[18] Liu Yuping, Wang Xiaodong, Zhao Qian. Analysis of CT manifestations and signs of bronchiolitis obliterans in children. Journal of Medical Imaging, 2016, 001(7):1327-1329.

[19] Liu Qunhui, Qu Wenjing, Chen Yan. Clinical study of integrated traditional Chinese and western medicine in the treatment of bronchiolitis obliterans in children. Community Medicine Journal, 2015, 13(001):36-38.

[20] Chang Li, Liu Zhuo, Wang Yuping, et al. Serum vascular endothelial growth factor expression in children with bronchiolitis obliterans and its correlation with the course of disease. Chinese Journal of Practical Pediatrics, 2016, 001(31):947-948.

[21] Zhen Junfeng, Zhang Lu, Cao Xinxin, et al. Clinical analysis of single center Castleman disease with paraneoplastic pemphigus and bronchiolitis obliterans. Journal of Chinese Academy of Medical Sciences, 2017, 39(004):492-498.

[22] Yin Zifu. Staged nursing care of children with bronchiolitis obliterans. Journal of Nursing Science, 2015, 30(017):32-34.

[23] Chen Junxing, Hong Qingshan, Wang Xiaoli, et al. The application value of multi-slice spiral CT in the classification and staging of infantile bronchiolitis obliterans. The Journal of Practical Medicine, 2017, 33(3):470-472.

[24] Lian Xinyi. Professor Xu Rongqian's clinical experience in treating pediatric bronchiolitis obliterans with external therapy. Global Chinese Medicine, 2016, 9(009):1089-1091.

[25] Zhang Xiaoyan, Lin Jiangtao, Jia Yuping, et al. A case of bronchiolitis obliterans associated with paraneoplastic pemphigus secondary to lymphoma and literature review. Chinese Journal of Respiratory and Critical Care, 2019, 018(001):70- 75.

[26] Xu Jing. The relationship between CMV reactivation and bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. Chinese Journal of Hematology, 2015, 36(005):389-392.