Acute lung injury is a common critical condition with complex disease and rapid disease progression, which can lead to acute and severe respiratory impairment and even life-threatening conditions. In the process of acute lung injury caused by endotoxin, the pathogenic factors include direct and indirect damage to the lung. In the pathogenesis, inflammatory response, oxidative stress, iron death and coagulation disorder influence each other, and work together to form a vicious cycle. In order to better understand the pathogenesis of acute lung injury and understand the whole process of the disease, this paper makes a preliminary discussion on the pathogenesis of endotoxin-induced acute lung injury in domestic and foreign journals in recent years, so as to provide a basis for further study of endotoxin-induced acute lung injury.

Qiujuan Zhao and Genping Lei. Research Progress of Endotoxin-Induced Acute Lung Injury. International Journal of Health and Pharmaceutical Medicine (2023), Vol. 4, Issue 1: 138-143. https://doi.org/10.38007/IJHPM.2023.040114.

[1] Shi, H. And Ren, C.S. (2013) Basic and clinical research progress of acute lung injury/acute respiratory distress syndrome. Chinese Journal of Lung Diseases (Electronic Edition), 6(04):63-68.

[2] Johnson Elizabeth, R. and Matthay Michael, A. (2010) Acute lung injury: epidemiology, pathogenesis, and treatment. Journal of aerosol medicine and pulmonary drug delivery, 23(4). https://doi.org/10.1089/jamp.2009.0775

[3] Tang, J.R., Michaelis, K.A., Nozik-Grayck, E., et al. (2013) The NF-kappaB Inhibitory Proteins IkappaBalpha and IkappaBbeta Mediate Disparate Responses to Inflammation in Fetal Pulmonary Endothelial Cells. J Immunol, 190(6) :2913-2923 . https://doi.org/10.4049/jimmunol.1202670

[4] Fujishima, S. and Aikawa, N. (1995) Neutrophil-mediated tissue injury and its modulation. Intensive Care Med, 21 (3) :277-285. https://doi.org/10.1007/BF01701489

[5] Meng, L., Song, Z., Liu, A., et al. (2021) Effects of lipopolysaccharide-bindingp protein (LBP) single nucleotide polymorphism (SNP) in Infections, inflammatory diseases, metabolic disorders and cancers. Front Immunol, 12: 681810. https://doi.org/10.3389/fimmu.2021.681810

[6] Rebetz, J., Semple, J.W. and Kapur, R. (2018) The pathogenic involvement of neutrophils in acute respiratory distress syndrome and transfusion-related acute lung injury. Transfusion Medicine and Hemotherapy, 45(5):290-298.DOI:10.1159/000492950.

[7] Kocak, H , Oner-Iyido an, Y., Gürd,L. F., et al. (2005) The relation between serum MDA and cystatin C levels in chronic spinal cord injury patients. Clin Biochem, 38 (11) :1034-1037. https://doi.org/10.1016/j.clinbiochem.2005.08.005

[8] Urban, M.V., Rath, T. And Radtke, C. Hydrogen peroxide(H2O2): a review of its use in surgery. -2.

[9] Huang, X.Y. and Liu, Y.L. (2017) Resveratrol activates Nrf2/ARE signaling pathway to reduce inflammation and oxidative stress in rats with myocardial ischemia-reperfusion injury.Chinese Journal of Traditional Chinese Medicine, 35(06):1516-1520. DOI: 10.13193/j.issn.1673-7717.2017.06.04.

[10] Zhang, H.Y., Zhao, B., Wang, Y.H. and Zhang, Y. (2021) Mechanism of Emodin Inhibiting Inflammation and Oxidative Stress by Regulating Nrf2/HO-1 and MAPKs. Chinese Journal of Immunology, 37(09):1063-1068.

[11] Konrad, F.M., Knausberg, U., Hoene, R., et al. (2016) Tissue heme oxygenase-1exerts anti-inflammatory effects on LPS-induced pulmonary inflammation.Mucosal Immunol, 9 (1) :98-111. https://doi.org/10.1038/mi.2015.39

[12] Yin, H., Xu, L. And Porter, N.A. (2011) Free radical lipid peroxidation:mechanisms and analysis. Chem Rev, 111(10):5944-597. https://doi.org/10.1021/cr200084z

[13] Yang, W.S., Sriramaratnam, R., Welsch, M.E., et al. (2014) Regulation of ferroptotic cancer cell death by GPX4.Cell, 156(1-2):317-33. https://doi.org/10.1016/j.cell.2013.12.010

[14] Grover, S.P. and Mackman, N. (2018) Tissue factor:an essential mediator of hemostasis and trigger of thrombosis. Arteriosclerosis,Thrombosis,and Vascular Biology, 38(4):709-725.DOI:10.1161/ATVBA-HA.117.309846.

[15] Graf, C. and Ruf, W. (2018) Tissue factor as a mediator of coagulation and signaling in cancer and chronic inflammation. Thrombosis Research,2018,164:S143-S147.DOI:10.1016/j.thromres. 01.023.