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International Journal of Health and Pharmaceutical Medicine, 2022, 3(1); doi: 10.38007/IJHPM.2022.030104.

Neurorehabilitation of Moderate-Intensity Aerobic Exercise for ATS Drug Dependent Compulsory Isolation Detoxification


Saade Metawa and Amaren Jaina

Corresponding Author:
Saade Metawa

Mansoura University, Egypt


ATS-type stimulants are highly neurotoxic and can cause significant cognitive impairment and psychotic symptoms. They are characterized by strong mental dependence and severe consequences for abuse. Therefore, it is of great significance to systematically understand the treatment method of ATS on human body, and to the treatment of ATS drugs dependent on compulsory isolation. This article focuses on the research of moderate-intensity aerobic exercise on the neurological rehabilitation of ATS-dependent drug dependence detoxification. This article uses a combination of quantitative and qualitative research to select eligible ATS abusers in a citys compulsory isolation detoxification center as the research object. Quantitative research uses the ATS questionnaire to survey new ATS abusers who meet the criteria. Qualitative research uses focus group interviews and case interviews, uses purposeful sampling, and uses semi-structured interview outlines as tools to collect and process data. The results of quantitative and qualitative research complement each other to verify and analyze and discuss together. The results of this paper show that the SOD index of people with ATS use disorder is less than that of healthy controls (14.78 ± 2.43 vs 15.98 ± 3.66, p <0.05). The experimental results show that there are nerve damages in people who rely on ATS drugs for compulsory isolation and detoxification. The damages tend to continue to increase after withdrawal. Moderate-intensity aerobic exercise for 10 weeks can slow down the aggravation of nerve damages.


ATS Research, Drug Dependence, Aerobic Exercise, Neurorehabilitation Training, Cognitive Function, Oxidative Stress

Cite This Paper

Saade Metawa and Amaren Jaina. Neurorehabilitation of Moderate-Intensity Aerobic Exercise for ATS Drug Dependent Compulsory Isolation Detoxification. International Journal of Health and Pharmaceutical Medicine (2022), Vol. 3, Issue 1: 36-47. https://doi.org/10.38007/IJHPM.2022.030104.


[1] Crevelin, E.J., Salami, F.H., Alves, M.N.R., et al.(2016) Direct Analysis of Amphetamine Stimulants in a Whole Urine Sample by Atmospheric Solids Analysis Probe Tandem Mass Spectrometry. Journal of The American Society for Mass Spectrometry, 27(5):944-947. https://doi.org/10.1007/s13361-016-1349-5

[2] Wright. J., Kenneally, M.E., Edwards, J.W., et al. (2015) Adverse Health Effects Associated with Living in a Former Methamphetamine Drug Laboratory - Victoria, Australia, MMWR. Morbidity and mortality weekly report, 2017, 65(52):1470-1473. https://doi.org/10.15585/mmwr.mm6552a3

[3] Singh, D., Mamat, R.B., Narayanan, S., et al. (2019) Prevalence of Amphetamine-Type Stimulants (ATS) use among clients in primary and private Methadone Maintenance Treatment (MMT) program in Kuantan, Malaysia . Journal of Substance Use, 24(4):1-6. https://doi.org/10.1080/14659891.2019.1642409

[4] Song, A., Yang, J., (2018) Determination of Six Amphetamine-Type Stimulants in Urine Samples Using Electro-Enhanced Single Drop Microextraction-Gas Chromatography. Se pu = Chinese journal of chromatography, Zhongguo hua xue hui, 36(8): 803. https://doi.org/10.3724/SP.J.1123.2018.03021

[5] Xue, X., Song, Y., Yu, X., et al. (2018) Olanzapine and Haloperidol for The Treatment of Acute Symptoms of Mental Disorders Induced by Amphetamine-Type Stimulants: A randomized controlled trial. Medicine, 97(8): e9786. https://doi.org/10.1097/MD.0000000000009786

[6] Li, J., Fu, J., Huang, X., et al. (2016) Predicting Hydration Free Energies of Amphetamine-Type Stimulants with a Customized Molecular Model. Journal of Physics: Condensed Matter, 28(34): 344001. https://doi.org/10.1088/0953-8984/28/34/344001

[7] Alharbi, F.F., El-Guebaly, N. Cannabis and Amphetamine-type Stimulant-induced Psychoses. Addictive Disorders & Their Treatment, 2016, 15(4): 190-200. https://doi.org/10.1097/ADT.0000000000000086

[8] Potrikeeva, O.L., Suprun, N.G., Ispulova, S.N., et al. (2017) Social Rehabilitation of Drug Addicts in Russia: Problems of Organization at the Current Stage and Prospects for Further Development. Man in India, 97(11): 489-500.

[9] Aliakbar, P., Bin, H.A.H.J., Tajularipin, S., et al. (2016) Effectiveness of Cognitive-behavioral Therapy in the Treatment of Iranian Male Drug Addicts at a State Rehabilitation Center. Global Journal of Health Science, 9(1): 94-. https://doi.org/10.5539/gjhs.v9n1p94

[10] Guerreiro, M.M. (2016) Attention Deficit-Hyperactivity Disorder in Patients in Rehabilitation of Drug Addiction. Arquivos de Neuro-Psiquiatria, 74(12): 951-952. https://doi.org/10.1590/0004-282x20160182

[11] Choi, G.H., Ko, H., Pedrycz, W., Singh, A.K., & Pan, S.B. (2020). Recognition System Using Fusion Normalization Based on Morphological Features of Post-Exercise Ecg for Intelligent Biometrics. Sensors, 20(24), 7130. https://doi.org/10.3390/s20247130

[12] Qin, Q., Yang, X., Zhang, R., Liu, M., and Ma, Y. (2022). An Application of Deep Belief Networks in Early Warning for Cerebrovascular Disease Risk. Journal of Organizational and End User Computing (forthcoming). https://doi.org/10.4018/JOEUC.287574

[13] Baringbing, A.T.D.P., Wimardhani, Y. (2020) Oral Cancer Awareness of Recovering Drug Addicts in the National Narcotics Board Drug Rehabilitation Center in The Republic of Indonesia. Open Journal of Stomatology, 72(5): 228-233.

[14] Jamshidi, F., Nazari, I., Malayeri, H.T., et al. (2016) Pattern of Drug Abuse in Addicts Self-Referred Drug Rehabilitation Centers in Khuzestan Province-Iran, 2014-2015. Archiwum medycyny sadowej i kryminologii, 66(1): 1-12. https://doi.org/10.5114/amsik.2016.62330

[15] Heidari, M., Ghodusi, M., Akbari, F.A., et al. (2018) Self-Esteem and Locus of Control in the Initial and Final Stages of Drug Withdrawal among Addicts Attending Rehabilitation Centers. Rawal Medical Journal, 43(2): 309-313. https://doi.org/10.1097/ADT.0000000000000128

[16] Camargo, C.H.F., Dornelles, Tarcísio Fanha, Barszcz, K., et al. (2016) Attention Deficit Hyperactivity Disorder and Drug Addiction Rehabilitation Patients. Arquivos De Neuro Psiquiatria, 74(12): 1003-1007. https://doi.org/10.1590/0004-282x20160163

[17] Ngassam, R.G.N., Ung, L., Ologeanu-Taddei, R., Lartigau, J., Demoly, P., Bourdon, I., Molinari, N., and Chiriac, A.M. (2022). An Action Design Research to Facilitate the Adoption of Personal Health Records: The Case of Digital Allergy Card. Journal of Organizational and End User Computing(forthcoming). https://doi.org/10.4018/JOEUC.288551

[18] Bertolazzi, A., Zanier, M.L. (2018) The Discretionary Treatment of Drug Addiction in Prison. Salute E Societa, 17(1): 59-72. https://doi.org/10.3280/SES2018-001005

[19] Azmi, A.A., Hussin, H., Ishak, S.I.D., et al. (2018) Drug Addicts: Psychosocial Factor Contributing to Relapse. MATEC Web of Conferences, 150(6): 05097. https://doi.org/10.1051/matecconf/201815005097

[20] Arora, P.C., Ragi, K.G.S., Arora, A., et al. (2019) Oral Health Behavior and Treatment Needs among Drug Addicts and Controls in Amritsar District: A Case-controlled Study. Nervenhlkunde, 10(02): 201-206. https://doi.org/10.4103/jnrp.jnrp_309_18

[21] Zhen-Song G., Ze-Hua C., Ling-Na L., et al. (2016) Rehabilitation Effect of Methadone Maintenance Combined with Cognitive-Behavioral Therapy and Family Synchronization Health Education for Drug Addicts. Journal of Community Medicine, 50(15): 9019-9026.

[22] Salmeh, K., Louni, A.S., Vahid, A. (2018) Dental and Oral Health Status of an Iranian Population of Drug Abusers: A Comparative Study. Tropical Journal of Pharmaceutical Research, 17(3):559-. https://doi.org/10.4314/tjpr.v17i3.24

[23] Abedallah Zaid Abualkishik, Sundus Naji AL-Aziz, (2022) The Regulation and Influence of Physical Exercise on Human Body's Neutrosophic Set, Respiratory System and Nervous System, International Journal of Neutrosophic Science, Vol. 18, No. 3, pp: 111-124 (Doi : https://doi.org/10.54216/IJNS.1803010 ) 

[24] Fu. X., Chen, K., Liao, X., et al. (2017) Case Report: Surgical Removal of a Migrated Needle in Right Ventricle of an Intravenous Drug User. Substance Abuse Treatment Prevention & Policy, 12(1): 51. https://doi.org/10.1186/s13011-017-0134-1

[25] Oscar Terán-Mendoza, Sira-Ramos D., Jesús Guerrero-Alcedo, et al. (2016) Frontal Symptoms, Self-Perceived Stress, and Subjective Memory Complaints in Substance Abusers. Rev neurol, 62(7): 296-302. https://doi.org/10.33588/rn.6207.2015298

[26] Lebedev, M.A., Nicolelis, M.A.L., (2017) Brain-Machine Interfaces: From Basic Science to Neuroprostheses and Neurorehabilitation. Physiological Reviews, 97(2): 767-837. https://doi.org/10.1152/physrev.00027.2016

[27] Carrico, A.W., Nil, E., Sophal, C., et al. (2016) Behavioral Interventions for Cambodian Female Entertainment and Sex Workers Who Use Amphetamine-Type Stimulants. Journal of Behavioral Medicine, 39(3): 502-510. https://doi.org/10.1007/s10865-016-9713-2 

[28] Wang, Y., Yan, K.J., Fan, C.X., et al. (2019) Altered Functional Connectivity of the Nucleus Accumbens Subdivisions in Amphetamine-Type Stimulant Abusers: A Resting-State Fmri Study. Bmc Neuroscience, 20(1): 66. https://doi.org/10.1186/s12868-019-0548-y