The purpose of this article is to observe the clinical efficacy of Compound Yizhihao Granules combined with traditional Chinese and western medicine in the treatment of viral myocarditis (VMC), and to observe the changes in myocardial ultrastructure and morphological changes of apoptosis, providing a new study of viral myocarditis method. The experiment was divided into two groups. Based on the establishment of a VMC animal model inoculated with Coxsackievirus B3 (CVB3), the pathological changes and apoptosis of myocardial cells were observed with an optical microscope and an electron microscope. The control group was treated with compound Yizhihao granules combined with traditional Chinese and western medicine for viral myocarditis. The pathological changes and apoptosis of myocardial cells were observed with light microscope and electron microscope. The experimental results proved that myocardial lesions and inflammatory cell infiltration were visible under light or electron microscopy in the mice of the experimental group 5 days after the virus inoculation. The lesions reached a peak at 7-9 days, and the lesions basically recovered at 35 days. VMC mice showed apoptosis-like changes in myocardial cells, and apoptotic bodies were seen 7-9 days after virus inoculation. The control group found that the Artemisia angustifolia group had significant therapeutic effects in clinical symptoms, electrocardiogram, echocardiography, improvement of myocardial damage indicators, and negative conversion of Coxsackievirus B3 (CVB3) and enterovirus-RNA. The total effective rate was 88.2% Compared with the taurine group, there was no significant difference (p> 0.05), compared with the control group (p <0.05). Conclusion the mice in the experimental group can cause abnormal myocardial cell apoptosis in VMC and VMC after inoculation with CVB. The compound Yizhizhi combined with astragalus and coenzyme and other traditional Chinese and western medicines have significant curative effects and is worthy of clinical popularization and application.

Lin Wang. Clinical Observation of Compound Yizhihao Granules Combined with Chinese and Western Medicine in Treating Viral Myocarditis. International Journal of Public Health and Preventive Medicine (2021), Vol. 2, Issue 2: 11-22. https://doi.org/10.38007/IJPHPM.2021.020202.

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