International Journal of Public Health and Preventive Medicine, 2022, 3(4); doi: 10.38007/IJPHPM.2022.030402.
Lei Xu, Yiying Wu, Wenjing Wang, Hang Li and Yanlong Zhao
Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an710000, China
Chronic renal failure (CRF) has become one of the chronic diseases that seriously damage human health worldwide. For the prevention and treatment of this disease, Chinese medicine has certain advantages due to its uniqueness. The diagnosis and treatment of chronic renal failure from the perspective of the combination of western medicine diseases and TCM syndrome types reflects the characteristics of TCM syndrome differentiation. The combination of disease and syndrome in animal models is widely needed in the connection between TCM clinical and basic experiments. Therefore, the successful construction of an animal model under the combination of disease and syndrome that conforms to the clinical characteristics of the disease has certain advantages for people to further understand the etiology and pathogenesis of the disease. This article reviews the research progress of CRF experimental animal models under the mode of combination of disease and syndrome, in order to provide a basis for the preparation of an animal models for TCM experimental research.
Chronic Renal Failure, Combination of Disease and Syndrome, Animal Model, Review
Lei Xu, Yiying Wu, Wenjing Wang, Hang Li and Yanlong Zhao. Research Progress of Experimental Animal Model of Chronic Renal Failure in Combination of Disease and Syndrome. International Journal of Public Health and Preventive Medicine (2022), Vol. 3, Issue 4: 9-18. https://doi.org/10.38007/IJPHPM.2022.030402.
 Liu, X. (2014) Chronic renal failure. Version 5. Beijing: People's Medical Publishing House, 524-532.
 Chen, X.M., Ni, Z.H., Liu, Y.N., Xie, Y.S., Sun, W. (2015) Chinese Journal of Integrated Traditional Chinese and Western Medicine, 35(09):1029-1033.
 Sun, W. (2016) Guidelines for the Diagnosis and Treatment of Chronic Renal Failure by Integrated Traditional Chinese and Western Medicine. Chinese Association of Integrated Traditional Chinese and Western Medicine Kidney Disease Professional Committee Academic Annual Conference Abstract, (2016):263-272.
 Yan, P., Wang, S.D., Xiao, Y.H., et al. (2018) Diagnosis and Treatment of Chronic Renal Failure. Global Journal of Chinese Medicine, 11(3):411-413. DOI:10.3969/j.issn.1671-3141.2013.03.094
 Hu, Q.S., Zhang, X.Y. Advances in Animal Models of Disease and Syndrome Combination. Journal of Traditional Chinese Medicine, 222,37(02):299-303.
 Zhong, S.J., Li, J., Li, L., Hu, S.Y., Yang, M., Huang, S.M., Xiong, X.J., Hu, Z.X. ((2021)) Review on the Research Ideas of Disease Syndrome Combined With Animal Model. China Journal of Traditional Chinese Medicine Information, 28(08):141-144.
 Huang, Y.Y. (2018) Research Status and Thinking of Animal Models Combining Disease and Syndrome. World Journal of Integrated Traditional Chinese and Western Medicine, 13(10):1459-1462
 Lin, C.Q. (2019) Research Progress and Existing Problems in Animal Model of Disease Syndrome Combination. Chinese Journal of Traditional Chinese Medicine, 34(8):3601-3604
 Ma, C.G., Ma, Y.R. (2018) Research Progress on Animal Models of TCM Syndrome. Journal of Chengdu University of Traditional Chinese Medicine, 41 (1):119-123.
 He, P.F., Gao, M., Zhang, Y., Ni, K., Guo, S.M. (2017) Research Progress In Animal Models of Acute And Chronic Renal Failure. Yunnan Journal of Traditional Chinese Medicine and Materia Medica, 38(12):80-84. DOI:10.3969/j.issn.1007-2349.2017.12.035
 Yang Liping, Liu Yongmei, Zhan Yongli, et al. Effect of Yiqi Qingre Ointment on renal tissue Wnt in rats with puromycin aminonucleoside nephrotic syndrome/ β- Effect of expression of catenin signaling pathway . Chinese Journal of Traditional Chinese Medicine, 2021, 36 (8): 4
 Wen Yumin. Study on therapeutic effect of Yiqi Qingre ointment on puromycin aminonucleoside nephropathy model rats. Beijing University of Traditional Chinese Medicine, 2012
 Bai, L., Bi, F.C., Zheng, Y.L. (2014) Expression and Significance of Nephrin and WT-1 in Podocytes of Puromycin Rat Model of Nephropathy. Ningxia Medical Journal, 36(03):201-203+192. DOI:10.13621/j.1001-5949.2014.03.0201
 Zhang, Y.Y. (2014) EGCG has A Protective Effect on Adriamycin Nephropathy by Reducing Oxidative Stress and Inhibiting NALP3 Inflammasome. Third Military Medical University. Expression and significance of HIF-1α, RhoA and SOX9 in adenine induced chronic kidney disease rat model. Chin J Comparative Med, 222,32(03):70-77+135.
 FujitsukaN. Chailing decoction can enhance the renal protective effect of cyclosporin A on rats given puromycin aminonucleoside . Foreign Medicine (Branch of Traditional Chinese Medicine), 2003 (003): 025
 Gao, Y., Diao, Z.L., Zhang, Q.D., Liu, W.H. ((2020)) Establishment of a Rat Model of Adenine-Induced Chronic Renal Failure and Changes of Calcium and Phosphorus Metabolism. Journal of Clinical Internal Medicine, 37(01):49-52.
 Lian, Q., Li, Q., Xie, Y.Y., Huang, X.L., Feng, Y.Y., Zheng, Z.G., Cao, K.F., Wang, Y.M., Luo, G.A. (2016) Chronic Renal Failure Induced by Adenine in Rats. Journal of Jiangxi University of Traditional Chinese Medicine, 28(06):93-97.
 Zhang, X.Y. Experimental Study of Shenshuai Formula in the Intervention of Adenine Induced Chronic Renal Failure Model Rats. Liaoning University of Traditional Chinese Medicine,2013.
 Stockelman MG, Lorenz JN, Smith FN, Et al. (1998) Chronic Takes its Failure in a Mouse Model of Human Adenine Phosphoribosyltransferase Deficiency. Am J Physiol, 275(1):F154-F163.
 Wang, R.Q., Wang, Y., Pu, J.J., Li, T., Liu, C. ((2011)) Establishment and Experience of Chronic Renal Failure Model In Rats. Journal of Medical Tribune, 32(19):20-23.
 Shang, X.M., Sun, X.L. Establishment of Chronic Renal Failure Model after 5/6 Nephrectomy in Rats. Journal of Baotou Medical College,(2015),31(04):20+22.
 Yang, K.X. (2016) Effect of Hei Dihuang Pill on Spleen Deficiency Syndrome of Chronic Renal Failure And Its Effect on Brain-Gut Peptide And Brain-Gut Axis. Shandong University of Traditional Chinese Medicine.
 Liu, H.F. (2016) Study on the Establishment of Miniature Pig Renal Failure Model by Minimally Invasive Surgical Technique and Intervention of RAAS System. Northeast Agricultural University.
 Cheng, Q.L., Xu, Y.Y., Yang, J., Qian, Y.L., Cao, X.J., Chen, S.F., Wang, C. (2017) Protective Effect of Yiqi, Yangxue, Quyu, and Jiezhu on Proteinuria And Residual Renal Function In 5/6(A/I) Chronic Renal Failure Rats. Chinese Journal of Integrated Traditional and Western Nephropathy, 18(07):570-573+608. https://doi.org/10.12677/ACM.2017.72015
 Sha, Z.H., Fu, P, Zhou, L., Tang, W.X., Liu, F., Li, J. Experimental Study on Chronic Renal Failure Model After 5/6 Nephrectomy in Rats. Sichuan Animal,(2006)(03):632-634+682.
Dani, M., Boisvert, C., Michaud, J. (2010) Down-Regulation of Liver Drug-Metabolizing Enzymes in A Murine Model of Chronic Renal Failure, 38 (3): 357-360.
 Wu, Y.S., Wan, Q., Shi, L.Q., Gao, J.D. Comparison Of Two Methods To Establish A Rat Model Of Chronic Renal Failure With Renal Anemia. Bengbu Medical College
 Jiang, Y. (2007).Experimental Study on the Renal Protective Effect of Zhenwu Decoction on Chronic Renal Failure Rats. China Academy of Chinese Medical Sciences.
 Li, X.Y., Li, D., Zhao, X.Z. (2010) Rapid Establishment of an Animal Model of Vascular Calcification Induced by Renal Failure In 5/6 Nephrectomy Rats with High Phosphorus Diet. Chinese Journal of Integrated Traditional and Western Nephropathy, 11(10):862-864+942.
 Liu, W.S., Meng, X.F., Zhang, N., Liu, S.W., Li, L.F., Zhu, H.W. (2015) Effects of Adenine Intragastric Administration Combined with High Phosphorus Diet on Vascular Calcification in Rats with Chronic Renal Failure. Chinese Journal of Integrated Traditional and Western Nephropathy, 16(12):1052-1055. https://doi.org/10.14725/gjicmwm.v3n1a1083
 Xiong, M.Y., Wang, Y. ((2021)) Chinese Journal of Integrated Traditional Chinese and Western Medicine Nephropathy, 22(11):1026-1027+1031.
 Lin, H.X., Wang, X.T., Ma, Y.H., et al. (2016) Effects of three modeling methods on kidney Yang deficiency. Shi Zhen Traditional Chinese Medicine and Pharmacology, 27 (4): 1015-1017.
 Zhou, H.M., Yang, J.P. (2016) Study on the Molecular Mechanism of Deficiency Induced Stasis in Chronic Renal Failure. Jiangxi Journal of Traditional Chinese Medicine, 47 (11):43-44.
 Zheng, P.F., Zhang, X.X., Wu, Y.J., Zhang, M.M., Yang, T., Zhao, Z.J. ((2021)) Establishment and Evaluation of Doxorubicin Combined with Hydrocortisone Induced Kidney Disease in Rats with Kidney Yang Deficiency Syndrome and Study on the Intervention Mechanism of Zhenwu Decoction. World Science and technology-Modernization of Traditional Chinese Medicine, 23(11):3887-3896.
 Zheng, P.F., Zhang, X.X., Zhao, Z.J. (2020) Research and Thinking on Animal Model of Kidney Yang Deficiency Syndrome in Chronic Kidney Disease. World Science and Technology - Modernization of Traditional Chinese Medicine, 22(01):47-52.
 Cui, Y.k., Gao, Y.Y., Gao, B.W., Yang, C.Q., Li, J. (2020) Effect of Zhenwu Decoction on The Expression of IL-17 In Rat Model of Kidney Yang Deficiency Edema. Chinese Journal of TCM Emergency,29(02):193-196.
 Fang, P., Su, J., Chen, W., Zhu, J.M., Yu, J.J., Yan, M.Q., Sun, C.C., Huang, Q.C., Liu, T., Chen, S.H., Lu, G.Y. (2020) Effect of clinking mountain pill on sexual dysfunction induced by adenine in kidney Yang deficiency rats. China Journal of Chinese Materia Medica, 45(10):2439-2445.
 Hong, C.L., Li, Z.M., Li, C.Y. (2015) Effect of Zhenwu Decoction on Renal Protection in Rats with Kidney Yang Deficiency Type Chronic Renal Failure. Journal of Zhejiang University of Chinese Medicine, 39(01):57-61.]
 Liu, X., Lan, J.M., Li, D.M. (2011) Effect of Jinkui Shenqi pills on plasma endothelin nitric oxide content in kidney-yang deficiency mice. Journal of Liaoning University of Traditional Chinese Medicine,3 (3) :186-188. (in Chinese)
 Sun, J.B., Xu, D.J., Hua, R. (2006) Protective Effect of Youguiyin on Kidney Yang Deficiency in Chronic Renal Failure Rats. Chinese Journal of Integrated Traditional and Western Medicine First Aid, 13(3):139-141
 Fu, X.Q., Lin, R.Q., Wu, Y.M., Hu, W.P., Chen, M., Xu, X.Y., Wu, S.L., Chen, X.F. (2003) Biochemical Study on Adenine Production of Chronic Renal Failure Model With Kidney Yang Deficiency. Journal of Fujian College of Traditional Chinese Medicine, (01):22-24. (in Chinese) DOI:10.3969/j.issn.1004-5627.2003.01.010
 Shi, H.X., Dong, Y.L., Yang, J.Q., et al. (2019) Effects of Warming Kidney And Strengthening Spleen on Visceral Sensitivity and Open-Field Experiment in Rats with Diarrhea-Type Irritable Bowel Syndrome. World Journal of Integrated Traditional Chinese and Western Medicine, 14(2): 207-210. DOI:CNKI:SUN:SJZX.0.2019-02-059
 Tan, W.L., Wu, Z.J., Zhang, D.P., et al. (2018) Effects of Fuzi Lizhong Decoction on Intestinal Mucosal NALP-3 Inflammasome and Other Immune Indexes in Rats with Diarrhea-Induced Irritable Bowel Syndrome. Chinese Materia Medica, 41 (4): 970-974. DOI:10.13863/j.issn1001-4454.2018.04.042
 Li, Y.J., Su, X.L., Yang, C., et al. (2017) Establishment and Evaluation of a Rat Model of Irritable Bowel Syndrome with Spleen-Kidney Yang Deficiency. Chinese Journal of Integrated Traditional and Western Medicine, 37 (8) : 950-954. DOI:10.7661/j.cjim.20170614.136