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International Journal of Public Health and Preventive Medicine, 2022, 3(2); doi: 10.38007/IJPHPM.2022.030204.

Monitoring and Analysis of Matrix Metalloproteinases in Saliva of Chronic Periodontitis Patients Based on Internet of Things Technology


Tredenick Julius

Corresponding Author:
Tredenick Julius

Tech Univ Sofia, Dept Elect Apparat, Sofia 1797, Bulgaria


Periodontitis not only leads to premature tooth loss in adults, but also induces various systemic diseases, which seriously affects the physical and mental health of patients. The purpose of this study was to understand the glycosylation level of EMMPRIN and the expression of GnT-V and MMP-2, 9 in healthy and inflamed periodontal tissues based on the Internet of Things. In vitro experiments, this paper recognizes the glycosylation level of EMMPRIN in cells cultured in vitro. In this study, 10 clinically healthy gingival tissues and 12 patients with severe periodontitis were collected, and the subjects' age. HGFs and HIOECs were cultured in vitro, the expression of EMMPRIN in primary HGFs and HIOECs was detected by Western Blot, and HIOECs were stimulated with different concentrations of Pg.LPS for different time periods. The expression of MMP-2, 9 was significantly increased in gingival connective tissue. In vitro experiments, Western Blot found that the glycosylation level of EMMPRIN increased in a concentration-dependent manner after HIOECs were stimulated by Pg. LPS (P<0.01). When 10μg/ml of Pg.LPS was stimulated for 12h, the glycosylation level of EMMPRIN was the highest.


Internet of Things Technology, Chronic Periodontitis, Matrix Metalloproteinases, Monitoring Analysis

Cite This Paper

Tredenick Julius. Monitoring and Analysis of Matrix Metalloproteinases in Saliva of Chronic Periodontitis Patients Based on Internet of Things Technology. International Journal of Public Health and Preventive Medicine (2022), Vol. 3, Issue 2: 47-61. https://doi.org/10.38007/IJPHPM.2022.030204.


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