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International Journal of Public Health and Preventive Medicine, 2022, 3(2); doi: 10.38007/IJPHPM.2022.030205.

Meta-analysis of Injection of Mitomycin after Glaucoma Surgery to Improves Clinical Outcome

Author(s)

Pisaniello Leng

Corresponding Author:
Pisaniello Leng
Affiliation(s)

University of Antwerp, Belgium

Abstract

The purpose of this article is to evaluate the efficacy and improved clinical differences in the treatment of glaucoma patients by using mitomycin C.Obtained related papers published in the past by searching MEDLINE, EMBASE, China Biomedical Literature Database, and Cochran Library. there are total 8 clinical controlled trials were included in the meta-analysis after screening. Compare the percent drop in tension, the success rate of treatment, the total success rate of treatment, and complications between combined use and no use of mitomycin C in non-penetrating trabecular surgery, and conduct statistical analysis. Results shows that the weighted mean difference in the percentage of tension drop is 5.24%. (95% CI, -3.24~13.72), 8.31% (95% CI, 4.33~12.30), 9.56% (95% CI, 4.88~14.24), 14.45% (95% CI, 9.02~19.88) in the combination of non-penetrating trabecular surgery with mitomycin C and simple non-penetrating trabecular surgery at 5, 12, 24, and 36 months after operation, There were statistically significant differences between the two groups at all other time points except 6 months after surgery (P<0.05).The complete success rate of non-penetrating trabecular surgery combined with mitomycin C was higher than that of the non-penetrating trabecular surgery group. The combined risk difference of treatment success rate was 1.16 (95% CI, 1.05~1.27), 1.20 (95% CI, 1.05~1.38), 1.30 (95% CI, 1.05~1.61), 1.36 (95% CI, 1.06). ~1.73) at 6, 12, 24, 36 months after surgery. There were no drug-related complications during combined application of mitomycin C. Conclusion: The combination of mitomycin C can improve the efficacy of glaucoma surgery and the tolerance is good.

Keywords

Glaucoma Surgery, Injection of Mitomycin, Meta-analysis

Cite This Paper

Pisaniello Leng. Meta-analysis of Injection of Mitomycin after Glaucoma Surgery to Improves Clinical Outcome. International Journal of Public Health and Preventive Medicine (2022), Vol. 3, Issue 2: 62-72. https://doi.org/10.38007/IJPHPM.2022.030205.

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