The purpose of this article is to evaluate the efficacy and improved clinical differences in the treatment of glaucoma patients by using mitomycin C.Obtained related papers published in the past by searching MEDLINE, EMBASE, China Biomedical Literature Database, and Cochran Library. there are total 8 clinical controlled trials were included in the meta-analysis after screening. Compare the percent drop in tension, the success rate of treatment, the total success rate of treatment, and complications between combined use and no use of mitomycin C in non-penetrating trabecular surgery, and conduct statistical analysis. Results shows that the weighted mean difference in the percentage of tension drop is 5.24%. (95% CI, -3.24~13.72), 8.31% (95% CI, 4.33~12.30), 9.56% (95% CI, 4.88~14.24), 14.45% (95% CI, 9.02~19.88) in the combination of non-penetrating trabecular surgery with mitomycin C and simple non-penetrating trabecular surgery at 5, 12, 24, and 36 months after operation, There were statistically significant differences between the two groups at all other time points except 6 months after surgery (P<0.05).The complete success rate of non-penetrating trabecular surgery combined with mitomycin C was higher than that of the non-penetrating trabecular surgery group. The combined risk difference of treatment success rate was 1.16 (95% CI, 1.05~1.27), 1.20 (95% CI, 1.05~1.38), 1.30 (95% CI, 1.05~1.61), 1.36 (95% CI, 1.06). ~1.73) at 6, 12, 24, 36 months after surgery. There were no drug-related complications during combined application of mitomycin C. Conclusion: The combination of mitomycin C can improve the efficacy of glaucoma surgery and the tolerance is good.

Pisaniello Leng. Meta-analysis of Injection of Mitomycin after Glaucoma Surgery to Improves Clinical Outcome. International Journal of Public Health and Preventive Medicine (2022), Vol. 3, Issue 2: 62-72. https://doi.org/10.38007/IJPHPM.2022.030205.

[1] Jun-Dong Zhu, Li-Lian Xie, Zhi-Yuan Li, & Xiao-He Lu. (2019) “The Prognosis of Trabeculectomy in Primary Angleclosure Glaucoma Patients”, International Journal of Ophthalmology, 12(01), pp. 70-76.

[2] Almobarak, Faisal A., Alharbi, Ali H., Morales, Jose, & Aljadaan, Ibrahim. (2017) “Intermediate and Long-term Outcomes of Mitomycin C–Enhanced Trabeculectomy As A First Glaucoma Procedure in Uveitic Glaucoma”, Journal of Glaucoma, 26(5), pp. 478-485.

[3] Lee, Y., Park, D.J., & Ko, S.K. (2014) “Cost-effectiveness Analysis of Latanoprost Compared with Dorzolamide/timolol Fixed Combination for the Treatment of Open-angle Glaucoma and Ocular Hypertension Patients in Korea”, Value in Health, 17(7), pp. A782-A782.

[4] Waterman, H., Bull S., Shaw M., & Richardson C. (2018) “Group-based Patient Education Delivered by Nurses to Meet a Clinical Standard for Glaucoma Information Provision: The G-train Feasibility Study”, Pilot & Feasibility Studies, 4(1), pp. 121.

[5] Qiu, C., & Qian, S. H. (2014) “Progress in Myopia and Open-angle Glaucoma Related Clinical Investigations”, Fudan University Journal of Medical Sciences, 41(3), pp. 419-424.

[6] Nishikawa, Takeshi, Sunami, Eiji, Tanaka, Toshiaki, Tanaka, Junichiro, Kiyomatsu, Tomomitsu, & Kawai, Kazushige. (2015) “Incidence and Prognostic Significance of Positive Peritoneal Lavage in Colorectal Cancer”, Surgery Today, 45(9), pp. 1073-1081.

[7] Liu, S. , Xing, S. H. , & Ophthalmology, D. O. (2014) “Clinical Observation of Glaucoma Trabeculectomy with Mitomycin C Treatment”, International Eye Science, 14(12), pp. 2256-2258.

[8] Almobarak, F. A., Alharbi, Ali H., Morales, Jose, & Aljadaan, Ibrahim. (2017) “The Influence of Mitomycin C Concentration on the Outcome of Trabeculectomy in Uveitic Glaucoma”, Int Ophthalmol,65(4), pp. 1-9.

[9] Saeed, A. M. , & Aboulnasr, T. T. (2014) “Subconjunctival Bevacizumab to Augment Trabeculectomy with Mitomycin C in the Management of Failed Glaucoma Surgery”, Clinical ophthalmology (Auckland, N.Z.), 8(12), pp. 1745-1755.

[10] Ossewaarde-Van Norel, J., ten Dam-van Loon, Ninette, de Boer, Joke H., & Rothova, Aniki. (2015) “Long-term Visual Prognosis of Peripheral Multifocal Chorioretinitis”, American Journal of Ophthalmology, 159(4), pp. 690-697.

[11] Zhou, M., Wang, Wei, Huang, Wenbin, & Zhang, Xiulan. (2014) “Use of Mitomycin C to Reduce the Incidence of Encapsulated Cysts Following Ahmed Glaucoma Valve Implantation in Refractory Glaucoma Patients: A New Technique”, BMC Ophthalmology, 14(1), pp. 107.