Artemisinin is a highly effective antimalarial component isolated from the Chinese medicine Artemisia annua. In addition to its antimalarial effect, artemisinin and its derivatives can also inhibit the activity of tumor cells. The glycosylation modification of artemisinin can solve the problem that it is prone to oxidation and isomerization and decompose and deteriorate. It is based on the principle that glycosyltransferase catalyzes the glycosylation reaction. This article aims to study the anti-tumor activity and mechanism of artemisinin galactosides, so this article selects derivatives with artemisinin as the mother core for structural transformation, screens them for activity, and selects a compound with high comprehensive evaluation. Its in vivo anti-tumor mechanism is studied. The selected dose is 20 mg / kg, 40 mg / kg, 80 mg / kg. During the experiment, the tumor diameter was measured every other day to calculate the tumor volume (V) and relative tumor volume (RTV). The relative tumor proliferation rate T / C (%) was used as the evaluation index of the drug's anti-MDA-MB-231 tumor activity in vivo. If T / C (%)> 60%, the drug was judged to be ineffective. The research data found that the tumor weight of artemisinin galactoside decreased as the dose increased, indicating that the tumor was dose-dependent on artemisinin galactoside and inhibited tumor at the highest dose (80 mg / kg) The rate reached 73.25%. Artemisinin drugs have a broad spectrum, high efficiency, and low toxicity, can selectively kill tumor cells, reverse the multi-drug resistance of tumors, and have a synergistic and synergistic effect with a variety of chemotherapy drugs.

Jianzhang Du. Anti-tumor Activity and Mechanism of Artemisinin Galactoside. International Journal of Public Health and Preventive Medicine (2020), Vol. 1, Issue 4: 34-45. https://doi.org/10.38007/IJPHPM.2020.010404.

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