The most common case of contemporary neuro-orthopedics and neurosurgery is sciatic nerve injury, but after the sciatic nerve is severed, it cannot be cured by medical surgery. Objective: To restore the damaged sciatic nerve to normal function. Methods: The rat model of sciatic nerve injury was made by operation after anastomosis of the sciatic nerve. A blank control group, model group and NT-3 treatment group were set up. Compare the recovery of rat sciatic nerve function and the pathological changes under the microscope before and after treatment. Results: The sciatic nerve function index of the rats before injury was all above 9, and the nerve function was completely normal. The SFI value of the high-dose group was close to 0 after the fourth week, which was significantly different from other groups (P <0.05), and its intensity Related to the concentration, the high-dose group had the most significant effect after statistical treatment; the recovery rate of calf triceps wet weight in the NT-3 high-dose group was higher than that of the other experimental groups, and the recovery rate at the sixth week was 77.35 %.The treatment effect is significant (P <0.01), the amplitude of the sciatic nerve action potential of rats before injury is higher than the amplitude of the sciatic nerve action potential of rats after injury, and the NT-3 high-dose group basically recovered to Normal nerve action potential amplitude (11.21). Conclusion: NT-3 can speed up the recovery of sciatic nerve function after sciatic nerve dissection.

Tao Jiang. Ultrasound Pathological Changes under Function and Microscope Observation after Sciatic Nerve in Rats. International Journal of Public Health and Preventive Medicine (2021), Vol. 2, Issue 3: 36-48. https://doi.org/10.38007/IJPHPM.2021.020304.

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