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International Journal of Public Health and Preventive Medicine, 2020, 1(3); doi: 10.38007/IJPHPM.2020.010301.

Effectiveness of Isazomil Combined with Lenadomide and Dexamethasone in the Treatment of Recurrent and Refractory Multiple Bone Marrow


Xianhua Qiao

Corresponding Author:
Xianhua Qiao

China Pharmaceutical University, Nanjing, China


With the increasing morbidity and mortality of patients with multiple myeloma (MM), new immunomodulatory agents, new-generation proteasome inhibitors, monoclonal antibodies and other new drugs have been introduced, but the therapeutic effects are not obvious. Ixazosamine, lenalidomide and dexamethasone are among the drugs for the treatment of MM patients. In order to find a more effective method for the treatment of MM, this article collected 21 patients with relapsed and refractory MM who received oxazide combined with lenalidomide and dexamethasone regimen from June 2014 to April 2018 in the Department of Hematology, Jinhua People's Hospital, Zhejiang Province. MM patients were treated with oxazolamide, lenalidomide and dexamethasone. In the MM patients in the study, 7 patients in the thalidomide exposure group and 6 patients in the unexposed group, the response rates of the two groups were 71% (5/7) and 67% (4/6), respectively. For thalidomide-resistant patients, the combination group still showed higher ORR and longer TTP and PFS than the dexamethasone monotherapy group. Lenalidomide combined with dexamethasone was effective in patients with relapsed and refractory MM with mild adverse reactions. This article also analyzed the efficacy of 61 patients with light chain, 153 patients with IgG and 39 patients with IgA MM who underwent autologous stem cell transplantation. The results showed that the median OS of patients with light chain MM was 2.8 years and the EFS was 1.2 years. Shorter than IgG-type MM patients (4.5 years, P = 0.03 and 2.1 years, P = 0.03). 


Multiple Myeloma, Thalidomide and Dexamethasone and Lenalidomide, Light Chain

Cite This Paper

Xianhua Qiao. Effectiveness of Isazomil Combined with Lenadomide and Dexamethasone in the Treatment of Recurrent and Refractory Multiple Bone Marrow. International Journal of Public Health and Preventive Medicine (2020), Vol. 1, Issue 3: 1-12.  https://doi.org/10.38007/IJPHPM.2020.010301.


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