Welcome to Scholar Publishing Group

International Journal of Sports Technology, 2022, 3(4); doi: 10.38007/IJST.2022.030405.

Sports on the Curative Effect of Breast Cancer Drug-Loaded Nanoparticle Drug Delivery System


Miaohong Gao

Corresponding Author:
Miaohong Gao

Guangdong Medical University, Dongguan, China


Breast cancer has become one of the malignant tumors with the highest incidence in the world. Malignant tumor is a disease that seriously threatens human health. Surgical treatment is difficult to achieve the ideal effect on advanced malignant tumors with extensive metastasis and recurrence. Based on the above background, the purpose of this article is to study the effect of sports on the curative effect of the drug-loaded nanoparticle drug delivery system against breast cancer. This study explores the effect of different exercise time combined with active peptide-modified drug-loaded nano-drug delivery system on breast cancer targeting; it aims to find ways to promote the effect of drug targeted therapy, and provide the role of exercise in tumor targeted therapy new basis. In this study, a comprehensive therapy of drugs combined with exercise was applied to nude mice bearing breast cancer Bcap-37 to observe the effect of exercise on drug treatment. The results of the study found that the exercise combined with PLA-PLL-RGD nano drug delivery system group was statistically significant compared with the exercise group and the saline group (p<0.05). Exercise with different exercise time can significantly promote the targeting effect of PLA-PLL-RGD nano drug delivery system on breast cancer tissue neovascularization. It shows that doing appropriate exercise while targeting tumor therapy can help increase targeted drugs to reach the tumor site, and can effectively inhibit tumor growth. Popularizing it in breast cancer treatment will help improve the recovery rate of patients.


Athletic Sports, Nanoparticle Drug Delivery System, Breast Cancer, Tumor Targeting

Cite This Paper

Miaohong Gao. Sports on the Curative Effect of Breast Cancer Drug-Loaded Nanoparticle Drug Delivery System. International Journal of Sports Technology (2022), Vol. 3, Issue 4: 64-78. https://doi.org/10.38007/IJST.2022.030405.


[1] Robert B, Mylène Dorvillius, Buchegger F, et al. Tumor targeting with newly designed biparatopic antibodies directed against two different epitopes of the carcinoembryonic antigen (CEA).. International Journal of Cancer Journal International Du Cancer, 2015, 81(2):285-291. DOI:10.1002/(SICI)1097-0215(19990412)81:2<285::AID-IJC19>3.0.CO;2-T 

[2] Juweid, M, Sharkey, R M, Behr, T M. Clinical evaluation of tumor targeting with the anticarcinoembryonic antigen murine monoclonal antibody fragment, MN-14 F(ab)2. Cancer, 2015,78(1):157-168. DOI:10.1002/(SICI)1097-0142(19960701)78:1<157::AID-CNCR22>3.0.CO;2-Y

[3] Lee I. Enhanced tumor targeting by an intratumoral injection of colloidal chromic 32P in two human tumors (AsPC-1 pancreas and Ls174T colon) in nude mice.. Journal of Surgical Oncology, 2015, 70(3):161-166. DOI:10.1002/(SICI)1096-9098(199903)70:3<161::AID-JSO3>3.0.CO;2-S

[4] Bo Gao, Ning Xu, Pengfei Xing. (2019) "Shock wave induced nanocrystallization and its effect on mechanical properties", Materials Letters, 237(15), pp. 180-184.

[5] Y Zhao, H Li, S Wan, A Sekuboyina, X Hu, G Tetteh, M Piraud, B Menze. Knowledge-aided convolutional neural network for small organ segmentation. IEEE journal of biomedical and health informatics, 23(4), pp:1363-1373, 2019.

[6] Murakami T, Delong J, Eilber F C, et al. Tumor-targeting Salmonella typhimurium A1-R in combination with doxorubicin eradicate soft tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) model. Oncotarget, 2016, 7(11):12783-12790. DOI: 10.18632/oncotarget.7226

[7] Hao Y, Zhang B, Zheng C, et al. The tumor-targeting core–shell structured DTX-loaded PLGA@Au nanoparticles for chemo-photothermal therapy and X-ray imaging. Journal of Controlled Release, 2015, 220(part_PA):545-555. DOI:10.1016/j.jconrel.2015.11.016

[8] T Kiyuna, T Murakami, Y Tome. High efficacy of tumor-targeting Salmonella typhimurium A1-R on a doxorubicin- and dactolisib-resistant follicular dendritic-cell sarcoma in a patient-derived orthotopic xenograft PDOX nude mouse model. Oncotarget, 2016, 7(22):33046-33054. DOI:10.18632/oncotarget.8848

[9] Kawaguchi K, Igarashi K, Murakami T, et al. Tumor-targeting Salmonella typhimurium A1-R combined with temozolomide regresses malignant melanoma with a BRAF-V600E mutation in a patient-derived orthotopic xenograft (PDOX) model. Oncotarget, 2016, 7(52):85929-85936. DOI:10.18632/oncotarget.13231

[10] Dissanayake S, Denny W A, Gamage S, et al. Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides. Journal of Controlled Release, 2017, 250(Complete):62-76. DOI:10.1016/j.jconrel.2017.02.006

[11] Sung, S., Lee, P., Hsieh, C., & Zheng, W. (2020). Medication Use and the Risk of Newly Diagnosed Diabetes in Patients with Epilepsy: A Data Mining Application on a Healthcare Database. Journal of Organizational and End User Computing (JOEUC), 32(2), 93-108. DOI:10.4018/JOEUC.2020040105

[12] Park D H, Cho J, Kwon O J, et al. Biodegradable Inorganic Nanovector: Passive versus Active Tumor Targeting in siRNA Transportation. Angew Chem Int Ed Engl, 2016, 55(14):4612-4612. DOI:10.1002/anie.201510844

[13] Lee J Y, Chung S J, Cho H J, et al. Phenylboronic Acid‐Decorated Chondroitin Sulfate A‐Based Theranostic Nanoparticles for Enhanced Tumor Targeting and Penetration. Advanced Functional Materials, 2015, 25(24):3705-3717.

[14] Pourjavadi A, Tehrani Z M, Moghanaki A A. Folate-Conjugated pH-Responsive Nanocarrier Designed for Active Tumor Targeting and Controlled Release of Gemcitabine. Pharmaceutical Research, 2016, 33(2):1-16. DOI:10.1007/s11706-017-0401-0

[15] Gao H, Zhang Q, Yang Y, et al. Tumor homing cell penetrating peptide decorated nanoparticles used for enhancing tumor targeting delivery and therapy. International Journal of Pharmaceutics, 2015, 478(1):240-250. DOI:10.1016/j.ijpharm.2014.11.029

[16] Hou J, Diao Y, Li W, et al. RGD peptide conjugation results in enhanced antitumor activity of PD0325901 against glioblastoma by both tumor-targeting delivery and combination therapy. International Journal of Pharmaceutics, 2016, 505(1-2):329-340. DOI:10.1016/j.ijpharm.2016.04.017

[17] Gu Q, Chen W, Duan F, et al. Fabrication of a nano-drug delivery system based on layered rare-earth hydroxides integrating drug-loading and fluorescence properties. Dalton Trans, 2016, 45(30):12137-12143. DOI:10.1039/c6dt01875k

[18] Hong T, Xue X M, He B. Research progress of endogenous exosomes as nano drug delivery system for treatment of myocardial ischemia. Journal of Shanghai Jiaotong University (Medical ence), 2018, 38(8):984-989.

[19] Al-Dhubiab B E, Nair A B, Kumria R, et al. Formulation and evaluation of nano based drug delivery system for the buccal delivery of acyclovir. Colloids & Surfaces B Biointerfaces, 2015, 136(12):878-884. DOI:10.1016/j.colsurfb.2015.10.045

[20] Kato S, Mori S, Kodama T. A Novel Treatment Method for Lymph Node Metastasis Using a Lymphatic Drug Delivery System with Nano/Microbubbles and Ultrasound. Journal of Cancer, 2015, 6(12):1282-1294.

[21] Nakata H, Miyazaki T, Iwasaki T, et al. Development of tumor-specific caffeine-potentiated chemotherapy using a novel drug delivery system with Span 80 nano-vesicles. Oncology Reports, 2015, 33(4):1593-1598.

[22] Huang C C, Lin P H, Lee C W. OFF/ON galvanic replacement reaction for preparing divergent AuAg nano-hollows as a SERS-visualized drug delivery system in targeted photodynamic therapy. RSC Advances, 2016, 6(69):64494-64498. DOI:10.1039/C6RA12971D

[23] Aldobaev V N, Prezent M A, Zavarzin I V. Shortened single-walled carbon nanotubes modification as design of nano-structural drug delivery system for pharmaceutical substances. Russian Chemical Bulletin, 2018, 67(11):2098-2102.

[24] Zeng Z, Li X, Zhang S, et al. Characterization of Nano Bamboo Charcoal Drug Delivery System for Eucommia ulmoides Extract and Its Anticancer Effect In vitro. Pharmacognosy Magazine, 2017, 13(51):498-503. DOI:10.4103/pm.pm_256_16

[25] Semnani D, Afrashi M, Alihosseini F, et al. Investigating the performance of drug delivery system of fluconazole made of nano-micro fibers coated on cotton/polyester fabric. Journal of materials science, 2017, 28(11):175.1-175.8. DOI:10.1007/s10856-017-5957-9

[26] Qiu L, Chen T, ??soy, Ismail, et al. A Cell-Targeted, Size-Photocontrollable, Nuclear-Uptake Nanodrug Delivery System for Drug-Resistant Cancer Therapy. Nano Letters, 2015, 15(1):457-463. DOI:10.1021/nl503777s

[27] Fahmy U A, Ahmed O A A, Hosny K M. Development and Evaluation of Avanafil Self-nanoemulsifying Drug Delivery System with Rapid Onset of Action and Enhanced Bioavailability. Aaps Pharmtech, 2015, 16(1):53-58. DOI:10.1208/s12249-014-0199-3

[28] Avachat A M, Patel V G. Self nanoemulsifying drug delivery system of stabilized ellagic acid–phospholipid complex with improved dissolution and permeability. Saudi Pharmaceutical Journal, 2015, 23(3):276-289.