International Journal of Health and Pharmaceutical Medicine, 2023, 4(2); doi: 10.38007/IJHPM.2023.040201.
Binqi Tian, Qianqian Gao and Xiaohong Cheng
Shaanxi Academy of Traditional Chinese Medicine, Xi’an 710003, Shaanxi, China
His methodological quality and the evidence quality of the outcome indicators of the systematic evaluation of oral Chinese herbal decoction in the treatment of primary nephrotic syndrome (PNS) were evaluated, so as to provide evidence for the treatment of primary nephrotic syndrome with oral Chinese herbal decoction. The databases of CNKI, WanFang Data, VIP, CBM, PubMed, The Cochrane Library and EMbase were searched for systematic evaluation or meta-analysis on the treatment of PNS with oral Chinese herbal decoction from the establishment of the database to November 30, 2022. Two researchers independently used AMSTAR2 scale to evaluate the methodological quality of the included study and GRADE system to evaluate the outcome indicators of the included study. A total of 11 items related to the systematic evaluation or meta-analysis of the treatment of PNS with oral Chinese herbal decoction were screened. The evaluation results of AMSTAR2 scale revealed that the 11 meta-analyses included were of extremely low quality. The GRADE system evaluation revealed that the evaluation results of five outcome indicators were intermediate (6.3%), 35 outcome indicators were low (44.3%), and 39 outcome indicators were extremely low (49.4%). Oral Chinese herbal decoction has certain clinical effect on the treatment of PNS, but there are many defects in the included systematic evaluation or meta-analysis in methodology. At the same time, the evidence quality of outcome indicators is low and more high-quality research results are urgently needed to provide evidence-based evidence support for clinical practice and provide guidance for clinical treatment of this disease.
Primary Nephrotic Syndrome, TCM, System Assessment
Binqi Tian, Qianqian Gao and Xiaohong Cheng. Systematic Evaluation and Reevaluation of Oral Chinese Herbal Decoction in the Treatment of Primary Nephrotic Syndrome. International Journal of Health and Pharmaceutical Medicine (2023), Vol. 4, Issue 2: 1-14. https://doi.org/10.38007/IJHPM.2023.040201.
 AGRAWAL S, ZARITSKY J J, FORNONI A, et al. Dyslipidaemia in nephrotic syndrome: mechanisms and treatment . Nat Rev Nephrol, 2018, 14(1): 57-70. https://doi.org/10.1038/nrneph.2017.155
 Wang Xiaofei, Zhang Ting, Liu Xun, Lu Xiaoying, Zou Hongbin. Progress in rituximab for the treatment of primary nephrotic syndrome. Middle National Medicine, 2021, 16 (03): 473-476.
 Hu Shunjin, Wang Fei, Guo Ruye, Ren Kejun, MAO Yanping, Liu Xiaoping, Zhang Li, Wang Yiping, Fang Qi. Treatment of 31 cases of primary nephrotic syndrome based on glucocorticoid administration stage syndrome differentiation. Journal of middle Medical College, Anhui Province, 2013, 32 (05): 19-23.
 Han Mei, Liu Jianping, Peng Rongyan, Yu Zeyu, Cao Huijuan. Data analysis method for systematic evaluation and reevaluation and middle research status in the field of medicine. middle Journal of Medicine, 2020,61 (17): 1525-1529.
 Niu Baihan, Zhai You, Zhang Mingyan, Zhang Ting, Li Kai, Wang Hui. Middle System evaluation and reevaluation of ventricular premature beats. World Science and Technology-middle Modernization of Medicine, 2021, 23 (10): 3735-3743.
 Yu Liang, Li Liqun, Liu Hongwu, Song Qingzeng, Tan Jinjing, Xie Sheng. Middle System evaluation and reevaluation of drug decoction for acute pancreatitis. Western middle Medicine, 2021, 34 (05): 85-91.
 Zhang Fangyuan, Shen Aomei, Zeng Xiantao, Qiang Wan Min, Jin Yinghui. System evaluation and methodological quality evaluation tool AMSTAR 2 interpretation. Middle National Journal of Evidence-based Cardiovascular Medicine, 2018,10 (01): 14-18.
 NONE. Grading quality of evidence and strength of recommendations. BMJ, 2004, 328. https://doi.org/10.1136/bmj.328.7454.1490
 Chen Yaolong, Yao Liang, Susan Norris, Du Liang, Chen Hao, Zeng Xiantao, MAO Zhi, Yang Kehu. GRADE focuses on the necessity and precautions of middle application in the systematic evaluation. Middle The National Journal of Evidence-based Medicine, 2013, 13 (12): 1401-1404.
 Zeng Xiantao, Leng Weidong, Li Sheng, Guo Yi, Wang Pu. How to correctly understand and use the GRADE system . middle National Journal of Evidence-based Medicine, 2011,11 (09): 985-990.
 Wang Hongyun. Exploring the efficacy and mechanism of intervening in primary nephrotic syndrome based on Meta-analysis and network pharmacology; Hubei middle Medical University.
 Ruan Dongdong. A meta-analysis of adult primary nephrotic syndrome. Hubei middle Medical University, 2021.
 Liu Jingwei. Meta-analysis of adult primary nephrotic syndrome and medication rule of Professor Zhang Daning. Tianjin middle Medical University, 2020.
 Li Mengdi. middle Meta-analysis of drug decoction combined with hormone for the treatment of primary nephrotic syndrome and the rule of medication treated by Professor Zhang Zongli. Tianjin middle Medical University, 2020.
 Liu Jiaojiao. Meta-analysis of patients in adult primary nephrotic syndrome. Hubei middle Medical University, 2019.
 Li Lijie. Drug use regularity and Meta-analysis of middle drugs for treating nephrotic syndrome. Jinan University, 2018.
 Xiao Xing, Tang Shuifu. Middle Systematic evaluation of the medical warming method in adults with primary nephrotic syndrome. Hunan middle Medical Journal, 2017,033 (006): 139-42.
 Han Shisheng, Xu Yanqiu, Wang Yi. Middle Systematic evaluation of the treatment of primary nephrotic syndrome. middle China middle Journal of Integrated Western Medicine nephropathy, 2015,16 (02): 136-139.
 Hu Shunjin, Wang Fei, Hu Yawen, et al. middle A matic evaluation of the efficacy of glucocorticoids in the treatment of primary nephrotic syndrome. middle Hua middle Medical Journal, 2014,29 (02): 395-8.
 Wang Yu, Dane Lai, Wei Jianhui. System evaluation of glucocorticoids combined with middle mediotheryang method in the treatment of primary nephrotic syndrome. Medicine and Philosophy (B), 2013, 34 (10): 37-40.
 ZHANG L, CHEN L. Systematic Review of the Efficacy and Safety of Traditional Chinese Medicine Granules Associated with Hormone When Treating Primary Nephrotic Syndrome in Children. Contrast Media Mol Imaging, 2022, 2022: 2520367. https://doi.org/10.1155/2022/2520367