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International Journal of World Medicine, 2023, 4(3); doi: 10.38007/IJWM.2023.040303.

Therapeutic Effect and Nursing Analysis of Nano-silver on High-risk Human Papillomavirus Infection in Obstetrics and Gynecology


Ying Wang

Corresponding Author:
Ying Wang

Linyi High-tech Hospital, Linyi, China

Philippine Christian University, Manila, Philippines 


HPV infection causes the proliferation of foreign body cells. Human papillomavirus produces cervical chronic inflammation, which is the main factor leading to cervical cancer, causes the continuous proliferation of cervical cells and gradually develops to malignancy. In this paper, the preparation model of nanoparticles was established to study the treatment of gynecological high-risk human papillomavirus infection according to the antibacterial, antibacterial and other properties of silver nanoparticles. The purpose of this paper is to analyze the advantages of nano silver and its feasibility in the treatment of high-risk human papilloma and cervical cancer. Through the statistical analysis of the data on the treatment effect and sense of use of 50 people infected with HPV with different degrees of infection, and at the end of the study, it will combine with the data and analyze the future research direction of nano silver. This paper states the importance of this study again, and give the corresponding countermeasures for the treatment of high-risk HPV infection. The data showed that the increase of HPV load was closely related to the risk of high-grade intraepithelial lesions and cervical cancer, while HPV load was significantly related to the size of internal lesions. Different factors have different effects on the silver content of composite antibacterial agents, among which the difference between the highest and lowest silver content of composite antibacterial agents is 1.9.


Nano Silver Particles, High-risk Human Papillomavirus, Antibacterial Materials, Cervical Cancer

Cite This Paper

Ying Wang. Therapeutic Effect and Nursing Analysis of Nano-silver on High-risk Human Papillomavirus Infection in Obstetrics and Gynecology. International Journal of World Medicine (2023), Vol. 4, Issue 3: 16-32. https://doi.org/10.38007/IJWM.2023.040303.


[1]Heidarpour M ,  Derakhshan M , M Derakhshan‐Horeh, et al. Prevalence of high‐risk human papillomavirus infection in women with ovarian endometriosis. The Journal of Obstetrics and Gynaecology Research, 2017, 43(1):135-139.

[2]Bennett S E . Should Women With High-risk Human Papillomavirus Infection of the Cervix Be Screened for Anal Squamous Intraepithelial Lesions?. Clinical Infectious Diseases, 2020, 70(6):1129-1130.

[3]Qiao Y P ,  Wang A L ,  Fang L W , et al. High-risk Human Papillomavirus Infection and Associated Factors among HIV-positive Women in High HIV-burden Areas of China. Biomedical and Environmental Sciences, 2020, 33( 3):206-212.

[4]Long D L ,  Song H L ,  Qu P P . Cytokines profiles in cervical mucosa in patients with cervical high-risk human papillomavirus infection. The Journal of Infection in Developing Countries, 2021, 15(5):719-725.

[5]Ba A A ,  Tlrmb C ,  Ahmb C , et al. Surrogate markers for high-risk human papillomavirus infection in oral epithelial dysplasia: A comparison of p16, Ki-67, and ProExC. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2020, 129( 3):246-259.

[6]Zhao S ,  Zhao X ,  Hu S Y , et al. Comparison of high-risk human papillomavirus infection rate and genotype distribution between Han and Mongolian women. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2019, 40(11):1439-1444.

[7]Yuanjing, Lyu, Ling, et al. Influencing Factors of High-Risk Human Papillomavirus Infection and DNA Load According to the Severity of Cervical Lesions in Female Coal Mine Workers of China.. Journal of Cancer, 2019, 10(23):5764-5769.

[8]Stensen S ,  Kjaer S K ,  Jensen S M , et al. Factors associated with type-specific persistence of high-risk human papillomavirus infection: A population-based study.. International Journal of Cancer, 2016, 138(2):361-368.

[9]Cai T ,  Perletti G ,  Meacci F , et al. Natural history of human papillomavirus infection in non-vaccinated young males: low clearance probability in high-risk genotypes. Eur J Clin Microbiol Infect Dis, 2016, 35(3):463-469.

[10]Yudira S ,  Maria L C ,  Licet G , et al. Molecular evidence of high-risk human papillomavirus infection in colorectal tumours from Cuban patients. Memorias Do Instituto Oswaldo Cruz, 2016, 111(12):731-736.

[11]CC  Cockerill,  Orvidas L J ,  Moore E J , et al. Detection of high-risk human papillomavirus infection in tonsillar specimens using 2 commercially available assays. Diagnostic Microbiology & Infectious Disease, 2016, 86(4):365-368.

[12]A Pańczyszyn,  Boniewska-Bernacka E ,  Gb G . Telomere length in leukocytes and cervical smears of women with high-risk human papillomavirus (HR HPV) infection. Taiwanese Journal of Obstetrics and Gynecology, 2020, 59(1):51-55.

[13]Buda A ,  Elisei F ,  Palazzi S , et al. Quality of Care for Cervical and Endometrial Cancer Patients: The Impact of Different Techniques of Sentinel Lymph Node Mapping on Patient Satisfaction. Annals of Surgical Oncology, 2016, 23(9):1-7.

[14]Jain S M ,  Bagde M N ,  Bagde N D . Awareness of cervical cancer and Pap smear among nursing staff at a rural tertiary care hospital in Central India. Indian Journal of Cancer, 2016, 53(1):63-66.

[15]Chao X P ,  Sun T T ,  Wang S , et al. Correlation between the diversity of vaginal microbiota and the risk of high-risk human papillomavirus infection. International Journal of Gynecological Cancer, 2019, 29(1):28-34.

[16]Lv P ,  Zhao F ,  Xu X , et al. Correlation between Common Lower Genital Tract Microbes and High-Risk Human Papillomavirus Infection. The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale / AMMI Canada, 2019, 2019(2):1-6.

[17]Shen, Keng, Zhang, et al. High-risk human papillomavirus infection clearance following conization among patients with cervical intraepithelial neoplasm grade 3 aged at least 45 years. International journal of gynecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2017, 136(1):47-52.

[18]Waniczek, Dariusz, Markowski, Oral and oropharyngeal papillomas are not associated with high-risk human papillomavirus infection. European archives of oto-rhino-laryngology: Official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS), 2017, 274(9):3477-3483.

[19]Lu H ,  Jiang P C ,  Zhang X D , et al. Characteristics of bacterial vaginosis infection in cervical lesions with high risk human papillomavirus infection. International Journal of Clinical and Experimental Medicine, 2016, 8(11):21080-21088.

[20]Yang, Huaitao, Zeng, et al. Prevalence of High-Risk Human Papillomavirus Infection in China Analysis of 671,163 Human Papillomavirus Test Results From China's Largest College of American Pathologists-Certified Laboratory. American Journal of Clinical Pathology: Official Publication of American Society of Clinical Pathologists, 2016, 145(5):622-625.

[21]Ahmed H B ,  Emam H E . Layer by Layer Assembly of Nanosilver for High Performance Cotton Fabrics. Fibers and Polymers, 2016, 17(3):418-426.

[22]Anjum S ,  Gupta A ,  Sharma D , et al. Development of novel wound care systems based on nanosilver nanohydrogels of polymethacrylic acid with Aloe vera and curcumin. Materials Science & Engineering C Materials for Biological Applications, 2016, 64(jul.):157-166.

[23]Li L ,  Zhao C ,  Zhang Y , et al. Effect of stable antimicrobial nano-silver packaging on inhibiting mildew and in storage of rice. Food Chemistry, 2017, 215(jan.15):477-482.

[24]Shanmugam C ,  Sivasubramanian G ,  Parthasarathi B , et al. Erratum to: Antimicrobial, free radical scavenging activities and catalytic oxidation of benzyl alcohol by nano-silver synthesized from the leaf extract of Aristolochia indica L.: a promenade towards sustainability. Applied Nanoscience, 2016, 6(5):711-723.

[25]Deus D ,  Kehrenberg C ,  Schaudien D , et al. Effect of a nano-silver coating on the quality of fresh turkey meat during storage after modified atmosphere or vacuum packaging. Poultry Science, 2017, 96(2):449-457.

[26]F  Gallocchio,  Cibin V ,  Biancotto G , et al. Testing nano-silver food packaging to evaluate silver migration and food spoilage bacteria on chicken meat. Food Additives & Contaminants: Part A, 2016, 33(6):1063-1071.