To study the correlation between uterine artery pulsatility index (UtA PI), serum 25 hydroxyvitamin D (25 - (OH) D) and angiogenesis factor (PLGF) in early pregnancy and preeclampsia. One hundred and fourteen pregnant women who delivered in our hospital from January 2022 to December 2022 were included in the study, of which 100 normal pregnant women were set as the control group; 7 cases of mild and 7 cases of severe preeclampsia were included. -(OH)D and PLGF in predicting preeclampsia. The blood pressure of pregnant women in the early-onset PE group group (107.45±11.45 mmHg and 156.56±15.45 mmHg) was higher than that of pregnant women in the late-onset PE group (105.45±11.23 mmHg and 153.56±11.21 mmHg) and the control group (82.76±6.12 mmHg and 131.01±11.45 mmHg) (P < 0.05), and the blood pressure level was higher in the late-stage PE group than in the control group (P < 0.05). The levels of 25-(OH)D (10.55±1.12ng/mL and 12.23±1.32ng/mL, respectively) and PLGF (34.43±6.23pg/mL and 38.56±7.45pg/mL, respectively) were lower in the early and late PE groups than in the control group (18.34±2.12pg/mL and 56.89±15.32pg/mL, respectively). Pearson analysis showed a negative correlation between UtA-PI and 25-(OH)D and PLGF (P < 0.05). Logistic regression equation results showed that all preeclamptic births were independently associated with UtA-PI, 25-(OH)D, and PLGF levels (P < 0.05). The equation was set: Logit (P) = 1.723*(age) + 1.589*(BMI) + 1.764*(blood pressure) + 1.634*(UtA-PI) + 1.231*(25-(OH)D) + 1.467*(PLGF) - 1.693. ROC was used to analyze the predictive models UtA-PI, 25-(OH)D, PLGF on the predictive value of preeclampsia, the results showed that the three combined had an AUC of (0.858) for preeclampsia, with a sensitivity of 88.75% and specificity of 82.20%, P < 0.05. The combined screening of UtA PI, serum 25 - (OH) D and PLGF in early pregnancy is of great significance in the prediction of preeclampsia. It can timely assess the risk of preeclampsia and provide basis for clinical diagnosis and intervention.

Yunxiao Li, Haifeng Cui, Jie Liu. A Study on the Correlation between UtA-PI, Serum 25- (OH) D, and PLGF in Early Pregnancy and Preeclampsia. International Journal of World Medicine (2023), Vol. 4, Issue 3: 33-42. https://doi.org/10.38007/IJWM.2023.040304.

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