Liping Chen, Xiuyu Tian, Jun Guo
Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou730050, Gansu, China
To investigate the efficacy and assess the safety of dual C therapy (CGMS combined with CSII) in the treatment of primary severe type 2 diabetes mellitus (T2DM). In this paper, 100 newly diagnosed severe type 2 diabetes patients admitted to our hospital from January 2020 to December 2021 were selected and divided into the control group (multiple subcutaneous insulin injections+finger tip blood glucose monitoring) and the observation group (double C therapy) with 50 cases each. The general information, blood glucose reaching time, blood glucose drift, insulin dosage, blood glucose, blood lipid level, fasting glucose (FPG), blood glucose 2h after meal (2hPG) The levels of hemoglobin (HbAlc), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and the therapeutic effect. In the observation group, the time taken to reach the blood glucose standard was recorded as 5.36±1.04d, shorter than that of the control group as 7.64±1.11d (P<0.05), and the blood glucose drift was recorded as 7.32±1.54cd mmol/L and insulin dosage was recorded as 0.65±0.08U/kg, both better than that of the control group as 5.17±1.03cd mmol/L, 0.51±0.02U/kg (P<0.05). 0.02 U/kg in the control group (P < 0.05); after treatment, FPG in the observation group was measured as 6.22 ± 0.04) mmol/L, 2hPG was measured as (9.52 ± 1.14) mmol/L, and HbAlc was (6.11 ± 0.65) %, which were better than the corresponding levels in the control group (P<0.05). The TC, TG, and LDL-C levels in this group were [(4.01±0.23) mmol/L, (1.56±0.44) mmol/L, and (3.01±0.23) mmol/L], respectively, all of which were lower than those in the control group (all P<0.05). ALT, CRE, and BUN were found to be comparable between the two groups before and after treatment (P>0.05); the overall effective rate was higher in the observation group (98.00% vs. 86.00%) and the incidence of hypoglycemia was lower in the observation group (0.2% vs. 18.00%) compared with the control group(P<0.05). The combination of CGMS and CSII in T2DM can improve the effect of blood glucose control, reduce the amount of insulin used to treat patients, shorten the time of reaching the standard of blood glucose, and reduce the incidence of hypoglycemia.
Dynamic blood glucose monitoring; Continuous subcutaneous insulin pump infusion; Type 2 diabetes; Security
Liping Chen, Xiuyu Tian, Jun Guo. Efficacy and Safety of CGMS Combined with Insulin Pump CSII in the Treatment of Newly Diagnosed Severe Type 2 Diabetes. International Journal of World Medicine (2023), Vol. 4, Issue 3: 93-102. https://doi.org/10.38007/IJWM.2023.040311.
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