Chronic heart failure is a common clinical disease, the final destination of various heart diseases, and one of the main causes of death in patients with cardiovascular disease, which has become a major disease threatening human life and health. Epidemiological investigations show that its 5-year survival rate is comparable to that of malignant tumors. Its incidence is increasing year by year and tends to be younger, which has become an important issue in the cardiovascular field. Therefore, it has become an important task for clinicians to actively treat chronic heart failure, improve patients' clinical symptoms, and reduce the re-hospitalization and death rates. In recent years, clinical trials have shown that TCM combined with conventional western drugs can significantly improve the clinical efficacy of chronic heart failure, improve patients' cardiac function and prolong life. The treatment of chronic heart failure with TCM has the advantages of overall regulation, diagnosis and treatment, and fewer adverse reactions, etc. Its clinical efficacy has been well received by clinicians. Its clinical efficacy has been recognized by the majority of patients and has become a hot spot of clinical research. Based on the literature reports in recent years, the article summarizes the research progress of Chinese medicine in the treatment of chronic heart failure to provide a better reference for the treatment of chronic heart failure by Chinese medicine.

Dan Qi, Jing Ma. Research Progress on Traditional Chinese Medicine in the Treatment of Chronic Heart Failure. International Journal of World Medicine (2024), Vol. 5, Issue 1: 76-86. https://doi.org/10.38007/IJWM.2024.050109.

[1](The Writing Committee of the Report on Cardiovascular Health and Diseases in China).Report on Cardiovascular Health and Diseases in China 2021:an Updated Summary. Chinese Circulation Journal,2022,37(6):553-578.

[2]GUO Mengyang, WANG Shoufu, XING Dongmei. Research progress of traditional Chinese medicine in the treatment of heart failure. Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease,2024,22(1):92-95.

[3]YANG Haiyan, JIN Yanrong, DING Zhe, et al.Theoretical analysis of WU Rong-zu's warming and strengthening Shaoyin in the treatment of chronic heart failure. China Journal of Traditional Chinese Medicine and Pharmacy,2017,32(3):1098-1100.

[4]XU Mengqi, WANG Qiang. A review on the TCM treatment of chronic heart failure. Clinical Journal Of Chinese Medicine,2023 15(36):65-68.

[5]FENG Yuming, LI Sining. The Relationship between TCM Syndromes and Onset Solar Terms in Patients with Heart Failure in Lingnan. Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease,2021,19(22):3927-3930.

[6]WU Han, LI Ping, WU Yan-ting, et al. Application of heart failure score in the relationship between TCM syndrome and heart function classification. Journal of Tongji University(Medical Science),2021,42(4):472-477.

[7]SHI Gang, ZHU Lin, ZHANG Yao, et al. Correlation between the distribution of traditional Chinese medicine syndromes and brain natriuretic peptide in chronic heart failure. China Practical Medicine.2021,16(26):161-163.

[8]LI Xingxing, WU Yang, FAN Zongjing, et al. Meta-analysis of correlation between TCM syndromes and left ventricular ejection fraction in chronic heart failure. China Medical Herald,2019,16(21):143-146, 150.

[9]ZHAO Yongjia, LIU Pan, DAI Xiaohua. Analysis of the distribution pattern of Chinese medicine symptoms and risk factors in patients with chronic heart failure combined with atrial fibrillation. Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease,202220(8):1453-1456.

[10]ZHANG Wei-Li, GAO Chen, LI Jie,et al. Relationship between Chinese medicine evidence and cardiac function grading in chronic heart failure. Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease,2021,19(21):3765-3767.

[11]ZHAO Meiying, LIU Pan, YUAN Liang, et al. Association and Cluster Analysis of Syndrome, Symptom, Tongue, Pulse, and Moss in 215 Patients with Heart Failure. Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease,2021,19(9):1464-1468.

[12]LI Yan, LIU Yang, SHI Xiaoyu, et al. Effects of medicine on mitochondrial dynamics of myocardial tissue from Astragalus scapularis on rats with heart failure. Lishizhen Medicine and Materia Medica Research,2021,32(3):520-523.

[13]Lü Xue-qi, GUO Cong-cong, XU Yue,et al. A proposed mechanism by which Qishen Yiqi dropping pill improves cardiac energy metabolism in rats with heart failure based on metabolomics and network pharmacology. Acta Pharmaceutica Sinica,2022,57(5):1387-1395. 

[14]AN Yipei, CHEN Peng, CHEN Yan,et al. Discussion on Mechanism of Guanxinning Tablets for Heart Failure Based on Network Pharmacology and Molecular Docking. New Chinese Medicine,2022,54(12):9-15. 

[15]KE Shuang-Qiao, ZHANG Ting, PANG Rui-Ming. Effect of Astragalus Injection on AngiotensinⅡ-Induced H9c2 Myocardial Apoptosis and Its Mechanism. Journal of Guangzhou University of Traditional Chinese Medicine,2022,39(4):914-919. 

[16]Cui Liangyu, Ma Jing, Zhang Xuexue,et al. AstragalosideⅣProtects Cardiac Function in Rats with Congestive Heart Failure with Preserved Ejection Fraction and Its Influence on Myocardial Microvascular Inflammatory Factors. Journal of Emergency in Traditional Chinese Medicine,2022,31(1):53-57.

[17]YANG Ying, ZHANG Wen-hua, DING Ming,et al. Research on Prevention and Control Mechanism of the Ligustrazine Up Regulates SERCA2a by Regulating Histone Acetylation in A Mouse Model of Heart Failure. Journal of Modern Laboratory Medicine,2021,36(6):34-40.

[18]ZHENG Yong-zhi, WANG Yan, YAO Cheng-zeng,et al. Research on Medication Regularity of Heart Failure by Masters of Traditional Chinese Medicine and National Famous Chinese Physicians. Guiding Journal of Traditional Chinese Medicine and Pharmacy,2020,26(14):152-155.

[19]Awaguli Dawuti, Ren Liwen, Wang Ranran, et al. Network Pharmacology Study of the Effective components of Traditional Chinese Medicine in the Treatment of Heart Failure. Pharmacology and Clinics of Chinese Materia Medica,2020,36(5):131-136.

[20]LIU Lili, WANG Guoliang. Effects of Astragalus Polysaccharides on the Energy Metabolism of Cardiomyocytes in Rats with Chronic Heart Failure. Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease,2022,20(3):420-426.

[21]Cui Liangyu, Ma Jing, Zhang Xuexue, et al. AstragalosideⅣProtects Cardiac Function in Rats with Congestive Heart Failure with Preserved Ejection Fraction and Its Influence on Myocardial Microvascular Inflammatory Factors. Journal of Emergency in Traditional Chinese Medicine,2022,31(1):53-57. 

[22]LI Yan, LIU Yang, SHI Xiaoyu, et al. Effects of medicine on mitochondrial dynamics of myocardial tissue from Astragalus scapularis on rats with heart failure. Lishizhen Medicine and Materia Medica Research,2021,32(3):520-523.

[23]DONG Zhuqin, LUO Ying, YANG Ming, et al. Intervention of different concentrations of aqueous extract from Semen Lepidii on heart function in rats with heart failure. China Modern Doctor,2020,58(11):38-42,193.

[24]CHEN Donglang, ZOU Peiyuan, LIN Mingjian. A study of the effect of ginseng on cardiac function and neuroendocrine factors in patients with heart failure. China Medicine And Pharmacy,2020,10(23):100-102,173.

[25]ZHANG Wei, ZHANG Yan, LI Na, et al. Explore the Mechanism of Renshen(Ginseng Radix Et Rhizoma) in the Treatment of Heart Failure Based on Network Pharmacology. Journal of Liaoning University of Traditional Chinese Medicine,2021,23(6):102-106. 

[26]LI Gang-min, PENG Cheng, XU Xin,et al. Cardiotonic effects of components from Lateralis Radix Praeparata on isolated rat hearts. Lishizhen Medicine and Materia Medica Research,2021,32(2):265-268.

[27]Yu Wuhua, Zhong Lingyun, Ye Xietao, et al.Regulatory Effect of Yinfupian and Yangfupian on RAAS System in Rats with Chronic Heart Failure. Pharmacology and Clinics of Chinese Materia Medica,2020,36(3):144-148. 

[28]BAI Dongyang, ZHANG Lihua. Influences of Salvia Miltiorrhiza Extract on Cardiac Function and Myocardial Cell Apoptosis in Rats with Heart Failure. Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease,2021,19(2):235-239.

[29]Gong Xue. Effect of lyophilized powder of Salvia miltiorrhiza on inflammatory indexes in elderly patients with heart failure. The Medical Forum, 2020,24(26):3763-3764.

[30]SONG Yuanyuan, SHI Pengxiao, YAN Hongjuan. Effects of TanshinoneⅡA on Ventricular Remodeling and PI3K/Akt Signaling Pathway in Rats with Heart Failure. Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease,2022,20(4):638-642.

[31]GONG Ping, XIE Yun, YAO Cheng-zeng. A Meta Analysis of Poria and Cinnamon Twig and Atractylodes Macrocephala and Licorice Decoction Combined with Ginseng and Aconite Decoction in the Treatment of Chronic Heart Failure. Henan Traditional Chinese Medicine,2022,42(3):337-342.

[32]LIU Fang, HUANG Jianrong, ZHANG Guoxiong, et al. Efficacy and effect on cardiac function of adding flavored warm-yang and water-liquid formula in the treatment of chronic heart failure.Inner Mongolia Journal of Traditional Chinese Medicine,2021,40(10):4-5.

[33]ZHOU Aiming, YANG Deqian, ZHAO Fenglin. Effects of Baoyuan Decoction and Xuefu Zhuyu Decoction on cardiac function and inflammatory factors in patients with chronic heart failure.China Medical Herald,2019,16(10):128-131.

[34]Zheng Meihua. Analysis of the effect of Shengweisan combined with sacubitril valsartan sodium tablets in the treatment of chronic heart failure with decreased ejection fraction in qi and yin deficiency evidence. Prevention and Treatment of Cardiovascular Disease,2021,11(22):12-14.

[35]LI Wenqian, YUAN Suyun, WEI Yihong, et al. Effect of Yiqi Yangyin Decoctionwith Ejiao(Colla Corii Asini)on Heart Function and Quality of Life in Chronic Heart Failure Patients. Liaoning Journal of Traditional Chinese Medicine,2021,48(3):59-61. 

[36]ZHANG Qian. Effect analysis of Buqi Changluo Decoction in treating chronic heart failure patients with coronary heart disease. Clinical Journal Of Chinese Medicine,2018,10(36):36-37.

[37]JIANG Xue, LI Guo-lin. Clinical effect of Buqi Changluo Recipe on chronic heart failure of coronary heart disease with Qi-deficiency and blood-stasis syndrome and its influence on inflammatory factors.China Practical Medicine,2022,17(2):4-7.

[38]WU Fengzhu, ZHANG Jiamei. Clinical Effect of Acupuncture at Neiguan Point on Chronic Heart Failure. Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease,2020,28(8):98-104.

[39]HUANG Huo-jian, CHEN Wu-jun, ZHUANG Hong-biao. The Effect of Chinese Medicine Packet Adjuvant Therapy in the Treatment of Chronic Heart Failure with Heart-Lung Deficiency Syndrome and Its Influence on Myocardial Injury and Ventricular Remodeling.Guiding Journal of Traditional Chinese Medicine and Pharmacy,2021,27(3):104-108.

[40]YANG Yan, YANG Xin. Effects of thunder fire moxibustion on cardiac function and immune function in elderly heart failure patients with Yang deficiency and water flooding type.Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease,2022,20(7):1265-1267.