To explore the expression of S100A8/A9 in the brain and serum of chronic sleep deprivation (CSR) mice. The protein expression of S100A8/A9 in the hippocampus of CSR mice and wild-type mice was detected by western blotting, the mRNA expression of S100A8/A9 in the hippocampus of CSR mice and wild-type mice was detected by RNA-sequencing, and the serum concentration of S100A8/A9 in CSR mice and wild type mice was detected by enzyme-linked immunosorbent assay (ELISA). 1) The protein expression of S100A8/A9 in the hippocampus of the CSR group was significantly lower than that in wild type group (P<0.05); 2) The mRNA expression of S100A8/A9 in the hippocampus of the CSR group was significantly lower than that in wild type group(P<0.05) 3) The serum concentration of S100A9 of CSR mice was significantly higher than that in wild type group (P < 0.0001), but there was no significant difference in the S100A8 expression between the CSR group and the control group. The expression of S100A8/A9 in the brain and serum of CSR mice is different, and we need more studies to explore the internal mechanism.

Yige Zheng, Qian Zhai, Wei Gao. Changes in the Expression Level of S100A8/A9 in Brain Tissue and Serum of Sleep-Deprived Mice. International Journal of World Medicine (2024), Vol. 5, Issue 1: 87-93. https://doi.org/10.38007/IJWM.2024.050110.

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