Myocardial ischemia-reperfusion injury (MIRI) is a serious injury to ischemic myocardium after blood flow recovery, and it is the focus and difficulty of cardiovascular disease treatment. The JAK/STAT signaling pathway is a double-edged sword in MIRI. The activation of STAT1 can promote cardiomyocyte apoptosis and aggravate myocardial injury. STAT3 can reduce myocardial injury by up regulating anti apoptotic protein, but inhibiting the activation of the JAK2/STAT3 signaling pathway under oxidative stress can protect myocardium.

Siyang Bai, Xinyu Yang, Henan Wang, Jingyi Wu, Xue Li. JAK/STAT Pathway as a Double-Edged Sword in Myocardial Ischemia-Reperfusion Injury. International Journal of World Medicine (2024), Vol. 5, Issue 1: 106-109. https://doi.org/10.38007/IJWM.2024.050113.

[1] Neri M, Riezzo I, Pascale N, et al. Ischemia/reperfusion injury following acute myocardial infarction: a critical issue for clinicians and forensic pathologists[J]. Mediators of inflammation, 2017, 2017.

[2] Zheng J, Chen P, Zhong J, et al. HIF 1α in myocardial ischemia reperfusion injury[J]. Molecular medicine reports, 2021, 23(5): 1-9.

[3] Lakota J. Molecular mechanism of ischemia—Reperfusion injury after myocardial infarction and its possible targeted treatment[J]. International Journal of Cardiology, 2016, 100(220): 571-572.

[4] Deng J. Advanced research on the regulated necrosis mechanism in myocardial ischemia-reperfusion injury[J]. International Journal of Cardiology, 2021, 334: 97-101.

[5] Yadav M, Kumari P, Yadav V, et al. Pharmacological preconditioning with phosphodiestrase inhibitor: an answer to stem cell survival against ischemic injury through JAK/STAT signaling[J]. Heart Failure Reviews, 2020, 25(2): 355-366.

[6] Xin P, Xu X, Deng C, et al. The role of JAK/STAT signaling pathway and its inhibitors in diseases[J]. International immunopharmacology, 2020, 80: 106210.

[7] Zhang Q, Wang L, Wang S, et al. Signaling pathways and targeted therapy for myocardial infarction[J]. Signal Transduction and Targeted Therapy, 2022, 7(1): 1-38.

[8] Liu H J, Wang C H, Qiao Z, et al. Protective effect of curcumin against myocardium injury in ischemia reperfusion rats[J]. Pharmaceutical Biology, 2017, 55(1): 1144-1148.

[9] Pipicz M, Demján V, Sárközy M, et al. Effects of cardiovascular risk factors on cardiac STAT3[J]. International Journal of Molecular Sciences, 2018, 19(11): 3572.

[10] Xu M, Li X Y, Song L. Baicalin regulates macrophages polarization and alleviates myocardial ischaemia/reperfusion injury via inhibiting JAK/STAT pathway[J]. Pharmaceutical biology, 2020, 58(1): 655-663.

[11] Ong S B, Hernández-Reséndiz S, Crespo-Avilan G E, et al. Inflammation following acute myocardial infarction: multiple players, dynamic roles, and novel therapeutic opportunities[J]. Pharmacology & therapeutics, 2018, 186: 73-87.

[12] Eid R A, Alkhateeb M A, Eleawa S, et al. Cardioprotective effect of ghrelin against myocardial infarction-induced left ventricular injury via inhibition of SOCS3 and activation of JAK2/STAT3 signaling[J]. Basic research in cardiology, 2018, 113(2): 1-16.

[13] Xie X J, Fan D M, Xi K, et al. Suppression of microRNA-135b-5p protects against myocardial ischemia/reperfusion injury by activating JAK2/STAT3 signaling pathway in mice during sevoflurane anesthesia[J]. Bioscience Reports, 2017, 37(3).

[14] Li H, Yao W, Liu Z, et al. Hyperglycemia abrogates ischemic postconditioning cardioprotection by impairing AdipoR1/Caveolin-3/STAT3 signaling in diabetic rats[J]. Diabetes, 2016, 65(4): 942-955.

[15] Zhou D, Ding T, Ni B, et al. Hydroxysafflor Yellow A mitigated myocardial ischemia/reperfusion injury by inhibiting the activation of the JAK2/STAT1 pathway[J]. International Journal of Molecular Medicine, 2019, 44(2): 405-416.