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International Journal of Health and Pharmaceutical Medicine, 2021, 2(4); doi: 10.38007/IJHPM.2021.020405.

Rats with Myocardial Ultrastructure Changes Caused by Heavy Exercise


Lu Che

Corresponding Author:
Lu Che

Shaanxi University of Technology, Shaanxi, China


To observe and study the ultrastructural changes of myocardium in the normal training mice and the overactive mice by establishing the exercise models of the mice with different amount of exercise. 90 rats were randomly divided into control group, general exercise group and high exercise group. All the mice began to carry out the experiment after a one-week adaptation cycle. The normal control group lived normally and did not exercise. The ordinary exercise group trained for 5 days a week. The limit speed was set at 20m/min, and the slope of the platform was 5%. The high-exercise group trained 7 days a week with a limit speed of 35m/min and a platform slope of 10%. During the whole exercise experiment, the electric stimulation method was used to force the rats to carry out exercise training, which lasted for 10 weeks. After the training, the mice lived normally for 20 weeks. Light microscopy, electron microscopy and immunohistochemistry were used respectively. The experimental data were processed by Sigmaplot scientific plotting system, and the experimental results were expressed by means of mean±standard deviation.The common movement group rats myocardial ultrastructure changes in myocardium will be physiologic hypertrophy, myocardial mitochondria of rats changed much, myocardial volume larger, myocardial swelling volume, myocardial structural integrity, cardiac muscle wire overall and orderly, mitochondrial membrane are clear and complete the nucleus has increased obviously and the number of nuclei increased significantly. The ultrastructure of the myocardium of rats in the high-intensity exercise group was distorted, the myofilament was cracked, the mitochondrial membrane was damaged and obviously incomplete, the granulosity was obvious, and the myocardial structure was damaged. The suitable aerobic exercise makes the cardiomyocytes adapt to the combination of cardiomyocytes and cardiomyocytes, which is helpful to the health of the heart and improves the function of the heart. Excessive exercise will make the heart to the unhealthy direction of development, damage the performance of the heart; the damage degree of myocardial structure was significantly correlated with the amount of exercise. Excessive exercise over a long period of time can lead to pathological changes in the heart muscle and an increased risk of sudden death.


Heavy Exercise, Myocardial Ultrastructure, Keep Moving, Mouse Experiment

Cite This Paper

Lu Che. Rats with Myocardial Ultrastructure Changes Caused by Heavy Exercise. International Journal of Health and Pharmaceutical Medicine (2021), Vol. 2, Issue. 4: 45-57. https://doi.org/10.38007/IJHPM.2021.020405.


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