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International Journal of Health and Pharmaceutical Medicine, 2020, 1(2); doi: 10.38007/IJHPM.2020.010205.

Exercise Training on Cardiac Cell Proliferation Induced by HGF and TGF-B1 Expression in Rats


Quanfu Lu

Corresponding Author:
Quanfu Lu

Chengde Medical College, Hebei, China


The highest incidence of cardiovascular disease is myocardial infarction and myocardial hypertrophy, these two diseases threaten the lives of patients at any time. The purpose of this article is to solve the problem of how exercise training induces the expression of HGF and TGF-β1 in the myocardium and to explore the effect of different HGF and TGF-β1 expression on the proliferation of myocardial cells. This paper designed a research experiment on rats. The rats were divided into groups and exercise training was carried out. After the training, the expressions of HGF and TGF-β1 in the rat myocardium were analyzed by immunohistochemistry and immunofluorescence detection and the proliferation of rat myocardial cells was studied. The results show that aerobic exercise can reduce the heart rate of rats by 17%, increase the occurrence rate of binuclear cells by 21%, increase the expression of myocardial HGF and TGF-β1 by 25%, and increase the expression of HGF and TGF-β1 in myocardial tissue can promote myocardium. The occurrence of cell proliferation and the upregulation of cardiomyocyte proliferation can effectively improve heart function, proving that exercise training has a good effect on the treatment and prevention of cardiovascular diseases.


Sport Training, HGF and TGF-β1 Expression, Cardiomyocyte Proliferation, Affect the Study

Cite This Paper

Quanfu Lu. Exercise Training on Cardiac Cell Proliferation Induced by HGF and TGF-B1 Expression in Rats. International Journal of Health and Pharmaceutical Medicine (2020), Vol. 1, Issue 2: 48-60. https://doi.org/10.38007/IJHPM.2020.010205.


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