With the development of an aging society, the elderly will not only get diabetes, but also face osteoporosis, arteriosclerosis (coronary artery disease, peripheral artery disease, cerebrovascular disease), malignant tumors, various organs transsexual. Therefore, the causes of diabetes, carotid atherosclerosis, and other diseases frequently encountered by the elderly are further studied to explore solutions. In this paper, the age-related diabetic carotid artery atherosclerosis and the functional changes of endothelial cells in the microscopic area were determined. The side wall WSS after carotid stenosis recovery was 0.11±0.02 Pa, and the control group WSS was 0.05±0.07 Pa. As a result, from a genetic point of view, genetic polymorphisms can determine the differences between different individuals in the intensity of inflammatory response (such as Aβ and lipid deposition), and ultimately affect the severity and prognosis of the disease. Changes in the volume of GM and cerebral cortex caused by type 2 diabetes cause problems with thinking and memory, making patients more prone to cognitive impairment.

Jianxue Zhang. Carotid Arteriosclerosis and Function Changes of Endothelial Cells in Senile Diabetic under Microscope. International Journal of Health and Pharmaceutical Medicine (2020), Vol. 1, Issue 1: 63-74. https://doi.org/10.38007/IJHPM.2020.010106.

[1] Jain, A. Tantia, P. Saini, K. Sulemani, A. A. & Agrawal, R. P. . (2016). “Ratio of Waist-to-Calf Circumference and Carotid Atherosclerosis in Patients of Type 2 Diabetes Mellitus”,Journal of the Association of Physicians of India, 64(3), pp.32-35.

[2] Kawasaki, M. Arai, Y. Takayama, M. Hirata, T. Takayama, M. & Abe, Y. et al. (2016). “Carotid Atherosclerosis, Cytomegalovirus Infection, and Cognitive Decline in the Very Old: a Community-Based Prospective Cohort Study”,Age, 38(2), pp.29. DOI: 10.1007/s11357-016-9890-5

[3] Wang, X. Li, W. Song, F. Wang, L. Fu, Q. & Cao, S. et al. (2018). “Carotid Atherosclerosis Detected by Ultrasonography: a National Cross-Sectional Study”,Journal of the American Heart Association, 7(8), pp.e008701. DOI: 10.1161/JAHA.118.008701

[4] Liontou, C. Chrysohoou, C. Skoumas, J. Panagiotakos, D. B. Pitsavos, C. & Stefanadis, C. . (2016). “Chronotropic Response during Treadmill Exercise and Subclinical Carotid Atherosclerosis after Adjusting for the Calibrated Score Risk Classification: a Cross-Sectional Study”,Heart & Vessels, 31(2), pp.129-136.

[5] Wu, Y. He, J. Sun, X. Zhao, Y. M. Lou, H. Y. & Ji, X. L. et al. (2017). “Carotid Atherosclerosis and its Relationship to Coronary Heart Disease and Stroke Risk in Patients with Type 2 Diabetes Mellitus”, Medicine, 96(39), pp.e8151. DOI: 10.1097/MD.0000000000008151

[6] Takuro, K. Masaaki, M. Shin, K. Satoko, O. Shiro, Y. & Hironori, M. et al. (2017). “High Pulse Wave Velocity Has a Strong Impact on Early Carotid Atherosclerosis in a Japanese General Male Population”, Circulation Journal, 81(3), pp.310-315.

[7] Balarini, G. M. Zandonade, E. Tanure, L. Ferreira, G. A. & Valéria Valim. (2016). “Serum Calprotectin is a Biomarker of Carotid Atherosclerosis in Patients with Primary Sjögren's Syndrome”, Clinical and experimental rheumatology, 34(6), pp.1006.

[8] Ng, Y. M. Lim, S. K. Kang, P. S. Kadir, K. A. A. & Tai, M. L. S. . (2016). “Association between Serum 25-Hydroxyvitamin D Levels and Carotid Atherosclerosis in Chronic Kidney Disease Patients”, BMC Nephrology, 17(1), pp.151. DOI: 10.1186/s12882-016-0367-7

[9] Luo, P. Wang, L. Zhu, H. Du, S. & Ding, S. (2016). “Impact of Atorvastatin Combined with Ezetimibe for the Treatment of Carotid Atherosclerosis in Patients with Coronary Heart Disease”, Acta Cardiologica Sinica, 32(5), pp.578-585.

[10] Liu, A. Yu, Z. Wang, N. & Wang, W. (2016). “Carotid Atherosclerosis is Associated with Hypertension in a Hospital-Based Retrospective Cohort”,International Journal of Clinical & Experimental Medicine, 8(11), pp.21932-21938.

[11] Carbonell, M. Castelblanco, E. Valldeperas, X. Betriu, àngels, Traveset, Alícia, & Granado-Casas, M. et al. (2018). “Diabetic Retinopathy is Associated with the Presence and Burden of Subclinical Carotid Atherosclerosis in Type 1 Diabetes”,Cardiovascular Diabetology,17(1), pp.66.

[12] Kubota, M. Yoneda, M. Watanabe, H. & Egusa, G. (2017). “Progression of Carotid Atherosclerosis in Two Japanese Populations with Different Lifestyles”, Journal of Atherosclerosis and Thrombosis, 24(10), pp.1069-1074.