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International Journal of Health and Pharmaceutical Medicine, 2020, 1(4); doi: 10.38007/IJHPM.2020.010401.

Metabolic Disorder of Amino Acids in Chronic Liver Disease and Progress in Treatment of Branched Chain Amino Acids


Yehua Wang

Corresponding Author:
Yehua Wang

Shanghai University of International Business and Economics, Shanghai, China


In recent years, the incidence rate of chronic liver disease is on the rise, and has become a global disease. Chronic liver disease is caused by long-term chronic liver injury, which will gradually develop into liver fibrosis, and severe liver fibrosis will lead to liver cirrhosis. The purpose of this study is to study the metabolic disorder of amino acids in chronic liver disease and the progress of branched chain amino acid therapy. This paper mainly introduces the disorder of amino acid metabolism and branched chain amino acids in chronic liver disease, and then collects the patients with chronic liver disease admitted to the Department of Gastroenterology of our hospital from January 2019 to December 2019. The patients were randomly divided into two groups: one group of ordinary treatment group, one group of branched chain amino acid treatment group, the general treatment group was treated with water-soluble vitamin liver protection, and the branched chain amino acid group was treated with intravenous drip column of 300ml branched chain amino acid. Then the clinical symptoms and signs, liver function, albumin and cytokines of the two groups were compared and analyzed before and after treatment. The results showed that: the clinical symptoms and signs, liver function, albumin and cytokines were significantly improved in the common group and BCAA group. Compared with the normal group, BCAA group increased appetite and edema of lower limbs by 15% and 47% respectively. The effect of BCAA on IGF-I and cytokine levels was better than that of water-soluble vitamin. Therefore, the effect of branched chain amino acids in the treatment of chronic liver disease is far better than that with water-soluble vitamins.


Chronic Liver Disease, Branched Chain Amino Acids, Liver Function, Cytokines

Cite This Paper

Yehua Wang. Metabolic Disorder of Amino Acids in Chronic Liver Disease and Progress in Treatment of Branched Chain Amino Acids. International Journal of Health and Pharmaceutical Medicine (2020), Vol. 1, Issue 4: 1-12.  https://doi.org/10.38007/IJHPM.2020.010401.


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