International Journal of Health and Pharmaceutical Medicine, 2021, 2(2); doi: 10.38007/IJHPM.2021.020204.
Inje University, South Gyeongsang Province, Korea
With the continuous development of medicine, antibiotics have become the commonly used drugs in many patients during the operation period. However, excessive use of antibiotics is harmful to human health. Objective to investigate the prophylactic use of antibiotics under microscope during the operation period of liver cancer in general surgery department of a hospital. In this paper, 248 patients with prophylactic application of antibiotics under microscope during the operation of liver cancer in general surgery were randomly selected. The basic information and medication situation of these patients were investigated and filled in, and then the data of each group were analyzed and counted. According to the investigation and analysis, 16.8% of the 248 patients used prophylactic antibiotics under the microscope 3 hours before operation, 7.2% after operation. Among them, 52 cases (23.76%) were treated with one combination of antibiotics, 102 cases (68.43%) with two drugs and 8 cases (4.61%) with triple drugs. A total of 24 kinds of antibiotics were involved in the survey. The most commonly used antibiotics were penicillin, cephalosporin, monocyclic β - lactam antibiotics, minocycline, doxycycline, tetracycline, oxytetracycline, lincomycin, clindamycin, vancomycin, norvancomycin, enoxacin and ofloxacin. Therefore, the situation of prophylactic use of antibiotics under microscope in patients with liver cancer in general surgery is basically reasonable, and a few patients use antibiotics for a long time after operation, which is not conducive to the recovery of patients after operation. Therefore, we should strengthen the management and distribution mechanism of antibiotics to ensure that patients can use antibiotics within a reasonable range.
Liver Cancer Surgery in General Surgery, Microscope Prevention, Preventive Use, Antibacterial Drugs
Hoon Kim. Prophylactic use of Antibiotics under Microscope in General Surgery for Liver Cancer. International Journal of Health and Pharmaceutical Medicine (2021), Vol. 2, Issue 2: 36-46. https://doi.org/10.38007/IJHPM.2021.020204.
 Harlaar, J. J. Gosselink, M. P. Hop, W. C. J. Lange, J. F. & Jeekel, H. (2012). Blood transfusions and prognosis in colorectal cancer: long-term results of a randomized controlled trial. Annals of Surgery, 256(5), 686-7. DOI: 10.1097/SLA.0b013e318271cedf
 Schulz, H. J. (2005). Endoscopic surgery in infants and children. European Journal of Pediatric Surgery, 15(05), 319-324. DOI: 10.1055/s-2005-865809
 Martini, N. Rusch, V. W. Bains, M. S. Kris, M. G. Downey, R. J. & Flehinger, B. J. et al. (1999). Factors influencing ten-year survival in resected stages i to iiia non-small cell lung cancer. Journal of Thoracic & Cardiovascular Surgery, 117(1), 32-38. DOI: 10.1016/S0022-5223(99) 70467-8
 Samarasam, I. Chandran, B. S. Sitaram, V. Perakath, B. Nair, A. & Mathew, G. (2006). Palliative gastrectomy in advanced gastric cancer: is it worthwhile?. 76(1-2), 60-63.
 Snarska, J. Puchalski, Z. Markewicz, W. Wasielica, M. & Usowicz, H. (2008). The role of the general surgeon in diagnosis and treatment of neoplasms diseases in the surgical ward of the podlaskie region. Contemporary Oncology / Wspólczesna Onkologia, 12(1), 25-29.
 WU You-jun, HE Jian-miao, YANG Bo, QIN Rong, CAO Zhi-yu, & DONG Li-guo. (2011). Clinical study on the effect of selective regional chemoinfusion on prognosis after radical gastrectomy for gastric cancer. Medical Journal of Chinese People’s Liberation Army, 36(11), 1211-1213. DOI: 10.1631/jzus.B1000197
 YANG Yang, CHENG Zhangjun, ZHOU Jiahua, YU Zeqian, WANG Lishan, & JIN Jiyang. (2016). Associating liver partition and portal vein ligation for staged hepatectomy in treatment of massive liver cancer with cirrhosis: a report of 2 cases and literature review. Chinese Journal of General Surgery, 25(7), 965-972. DOI: 10.3978/j.issn.1005-6947.2016.07.006
 Cheslyn-Curtis, S. Fielding, L. P. Hittinger, R. Fry, J. S. & Phillips, R. K. . (1990). Large bowel cancer: the effect of perioperative blood transfusion on outcome. Annals of the Royal College of Surgeons of England, 72(1), 53. DOI: 10.1097/00000658-199001000-00017
 Akagi, Y. Shirouzu, K. Fujita, S. Ueno, H. Takii, Y. & Komori, K. et al. (2012). Predicting oncologic outcomes by stratifying mesorectal extension in patients with pt3 rectal cancer: a japanese multi-institutional study. International Journal of Cancer Journal International Du Cancer, 131(5), 1220-1227.
 Deacon JM, Pagliaro AJ, Zelicof SB, & Horowitz HW. (1996). Prophylactic use of antibiotics for procedures after total joint replacement. Journal of Bone & Joint Surgery American Volume, 78(11), 1755-70. DOI: 10.1097/00019048-199705000-00008
 Mercuri, L. G. & Psutka, D. (2011). Perioperative, postoperative, and prophylactic use of antibiotics in alloplastic total temporomandibular joint replacement surgery: a survey and preliminary guidelines. Journal of Oral & Maxillofacial Surgery, 69(8), 2106-2111. DOI: 10.1016/j.joms.2011.01.006
 None. (2008). Meta-analyses on the prophylactic use of antibiotics in acute pancreatitis: many are called but few are chosen. American Journal of Gastroenterology, 103(7), 1837-1838. DOI: 10.1111/j.1572-0241.2008.01959_5.x
 Clark, C. H. (1980). Prophylactic use of antibiotics in surgery. Part i. Modern veterinary practice, 61(2), 122-126. DOI:10.1016/S0091-0279(78)50030-0
 Mounzer, K. C. & Dinubile, M. J. (1997). Prophylactic use of antibiotics and vaccines in patients with rheumatologic disorders. Rheumatic Disease Clinics of North America, 23(2), 259-275. DOI: 10.1016/S0889-857X(05)70329-X
 Voros, D. C. (2018). The prophylactic use of antibiotics in surgery. Hellenic Journal of Surgery, 90(2), 61-61. DOI: 10.1007/s13126-018-0439-1
 Kuhlmann, I. (1995). The prophylactic use of antibiotics in cell culture. Cytotechnology, 19(2), 95-105. DOI: 10.1007/bf00749764