To study the effect of diving on the histopathological morphology and ultrastructure of heart apparatus. 24 rats were randomly divided into control group, 6ata air group and 6ata normoxia high nitrogen group, 8 rats in each group. The control group took food at will under natural light. The experiment was carried out after one week of observation and quarantine. The other two groups were exposed to 4 ATA and 6 ATA with air and pure nitrogen respectively for 30 minutes. The effects of different high-pressure exposure schemes and time courses on the morphology and ultrastructure of rat heart were observed. The effects of different exposure schemes on myocardial histopathology and expression of myocardial ET-1 were observed. Meanwhile, the content of plasma ET-1 was measured, compared and statistically analyzed. In the heart rate comparison, the heart rate of air group decreased by 7% (P < 0.01) when it was pressurized to 4 ATA, 9% (P < 0.01) when it was pressurized to 6 ATA, and there was no significant change in the heart rate of normoxia and high nitrogen group when it was pressurized to 4 ATA and 6 ATA, and within 30 minutes after 6 ATA exposure. In the comparison of blood pressure, systolic blood pressure increased by 5% (P < 0.05), diastolic blood pressure increased by 11% (P < 0.05), and mean arterial pressure increased by 9% (P < 0.05). There was no significant change in pulse pressure. When the normoxia group was pressurized to 6ata, systolic blood pressure increased by 8% (P < 0.01) and pulse pressure increased by 19% (P < 0.01). No obvious pathological changes were found in the myocardium. On the expression of ET-1 in myocardium, the expression of ET-1 in vascular endothelium was significantly increased in normoxia and hyperhelium group and air group.

Chadia Altrjmana and Rashare Almajede. Histopathological Morphology and Ultrastructure of the Heart Apparatus by Diving. International Journal of Health and Pharmaceutical Medicine (2022), Vol. 3, Issue 1: 48-59. https://doi.org/10.38007/IJHPM.2022.030105.

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