With the development of economy and the improvement of medical level, the treatment technology of osteoarthritis has also made a great breakthrough. At present, surgical treatment is the mainstream way for patients with severe disease. Although surgical treatment can solve the problem of cartilage damage, it is still not enough to fundamentally treat the disease. It is the key to achieve the goal of cartilage repair. In view of the lack of research in this field, this paper proposed platelet rich plasma combined with collagen matrix to promote the regeneration of articular chondrocytes and the effect of nanoparticles on oxygen free radicals. The research of this paper is mainly divided into three parts. The first part is the research of theoretical basis and core concepts. Through this part of the study, we believe that PRP and collagen matrix can strengthen the self-healing ability of tissue, and achieve ideal effect in theory. The second part is animal experimental model. Based on the above theoretical basis, the experimental model of white rabbit is established. In order to compare the experimental effect, 18 rabbits were randomly divided into two groups, 9 in each group. In the third chapter, the experimental principle and design scheme are given in detail. The third part is a comparative experiment. In order to verify the actual effect of this model, a number of experimental analysis including histological observation of new cartilage, biomechanical properties of new cartilage and expression of type II collagen were carried out. Through the analysis of experimental data, PRP combined with collagen matrix accelerated the regeneration of articular chondrocytes, and had a close relationship with the effect of nanoparticles on oxygen free radicals.

Qiumin Li. Platelet Rich Plasma Combined with Collagen Matrix Promotes Chondrocyte Regeneration in Arthritis and the Effect of Nanoparticles on Oxygen Free Radicals . International Journal of Educational Innovation and Science (2022), Vol. 3, Issue 4: 69-81. https://doi.org/10.38007/IJEIS.2022.030406.

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